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Reporter: 冯文婧

Explore effective way to increase acid resistance of lactococcus lactis F44 for higher production of nisin. Reporter: 冯文婧. Background. Nisin is a 34-amino acid antimicrobial peptide with various unusual amino acids and five ring structures. Broad host spectrum. easily being digested.

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Reporter: 冯文婧

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  1. Explore effective way to increase acid resistance of lactococcus lactis F44 for higher production of nisin Reporter: 冯文婧

  2. Background • Nisin is a 34-amino acid antimicrobial peptide with various unusual amino acids and five ring structures

  3. Broad host spectrum easily being digested preservative

  4. limitation for higher production Non-appropriate pH value Nisin degrades quickly when pH value higher than 4.0 (data not shown) Degradation from Protease The contradiction between the optimum growth pH (7.2) of L.lactis and stability of nisin(pH2.0). Improve acid resistance of L.lactis by transforming acid tolerance genes

  5. Review about acid resistance genes

  6. Overexpressing genes underlined in blue circle, to verify the influence these exert on nisin production

  7. Screening for genes based on nisin production

  8. Our goal

  9. Thank You !

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