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A:. In-vivo minigene In-vitro RNA template. Exon 11 skipping: HepG2 HeLa. Intron. GA INH. pIRA pIRC pIRK pIRL. A:. 255 nt. 11. 10. 14% 13%. 188 nt. 0% 0%. C:. 151 nt. 51% 68%. K:. 84 nt. 22% 17%. L:. B:.

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  1. A: In-vivo minigene In-vitro RNA template Exon 11 skipping: HepG2 HeLa Intron GA INH pIRA pIRC pIRK pIRL A: 255 nt 11 10 14% 13% 188 nt 0% 0% C: 151 nt 51% 68% K: 84 nt 22% 17% L: B: 5’ss: - Natural Consensus A C K L A C K L A C K L * * * * * * * * * * * * * * * * * * * * * * * * * C: Splicing Efficiency (%)

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