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ZOFRAN

ZOFRAN. Barry Barkinsky EMS-I, Paramedic. pharmacodynamics. Racemic form of ondansetron- a selective blocking agent of serotonin 5ht3 antagonist. pharmacokinetics.

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ZOFRAN

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  1. ZOFRAN Barry Barkinsky EMS-I, Paramedic

  2. pharmacodynamics • Racemic form of ondansetron- a selective blocking agent of serotonin 5ht3 antagonist

  3. pharmacokinetics • Excreted renally – patients with mild to moderate renal impairment have a 2-fold increase in retention time – mean half life increases to 11.6 hrs versus 5.7 hours in normal • No reduction in dose or dosing is called for in these patients

  4. Indications/Contraindications • INDICATED FOR : • Intractable vomiting and/or vertigo • Prevention of postoperative vomiting / nausea • CONTRAINDICATION • Known hypersensitivity to the drug

  5. Protocol • Routine paramedic care • Consider IV access and fluid resuscitation for dehydration and/or shock • For patients with patent airway and retractable vomiting: • Administer Zofran 4 mg ODT • Do not push through the foil backing – peel away • IMMEDIATELY place the Zofran ODT on top of the tongue where it will disolve in seconds • Giving with liquid is not necessary • No repeat is indicated

  6. BE ALERT FOR • Signs and symptoms of dystonic reaction • Administer 50-100 mg of benadryl IV or deep IM

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