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Integumentary System

Integumentary System. Altered Functions. Vocabulary. Derma- Melan/o- Pachy- Sub- trich/o- Cyan/o- Onych/o-. Xer/o- Hidr/o- Kerat/o- Xanth/o- Follicul/o- Dactyl/o- Intra-. Skin Epidermis Dermis Hypodermis Sensory receptors Muscle Adnexa Hair and follicle Glands Sweat

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Integumentary System

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  1. Integumentary System Altered Functions

  2. Vocabulary Derma- Melan/o- Pachy- Sub- trich/o- Cyan/o- Onych/o- Xer/o- Hidr/o- Kerat/o- Xanth/o- Follicul/o- Dactyl/o- Intra-

  3. Skin Epidermis Dermis Hypodermis Sensory receptors Muscle Adnexa Hair and follicle Glands Sweat Sebaceous Nails Integumentary Regions

  4. Epidermis Histology Overview

  5. Epidermis Strata Histology C = corneum G = granulosum S = spinosum B = basale

  6. Genetic Connective tissue Blood supply Neoplasia Drug Reactions Immune Underlying Disorders

  7. Primary Lesions • Macules: colored circumscribed flat area, size varies, < 1cm • Papules: discolored raised area, < 2cm • Plaques: raised flat top area, > 1cm • Patches: circumscribed flat area of discoloration, < 1cm • Nodules: solid raised area, above or below skin, <1 cm • Tumor: discolored raised area, > 2cm • Wheals: slightly raised area with edema, size varies • Vesicles/Blister: fluid filled raised area < 0.5cm • Bulla/Cyst: fluid filled raised area, > 0.5cm • Pustules: pus-filled raised area, size varies

  8. Macule

  9. Nodule

  10. Papule

  11. Bulla

  12. Erosions Ulcers Fissures Cracks Scales Excoriation Keloid Scar Lichenification Secondary Lesions

  13. Cracks and Fissures

  14. Ulcer and Erosion

  15. Excoriation

  16. Lichenification

  17. Scar Formation

  18. Keloid

  19. Epidermal Cells

  20. Keratinocytes

  21. Keratinocyte Hypertrophy

  22. Melanocyte location and function

  23. Melanosomes with Melanin

  24. Melanin

  25. Melanosis

  26. Langerhans Dendritic Cells

  27. Skin Cancers

  28. Skin Cancer ABCD and E (evolving)

  29. UV exposure UV A UV B Genetic Prevention Sun block UVA UVB Clothing Window tinting Etiology

  30. Benign Seborrheic keratitis Keratocanthoma Verucae (warts) Actinic keratitis Malignant Basal Cell carcinoma Squamous Cell carcinoma Dysplastic nevi Malignant melanoma Skin Tumors

  31. Seborrheic Keratosis

  32. Keratocanthoma

  33. Verrucae

  34. Actinic Keratitis

  35. Basal Cell Carcinoma

  36. Squamous Cell Carcinoma

  37. Epidermal Cancers Compared

  38. Malignant Melanoma

  39. Merkel Cell Carcinoma

  40. Dermis

  41. Dermal Papilla and Reticular Dermis

  42. Lines of Cleavage

  43. Aging = Wrinkles? • Skin changes • Chronological aging • Photo-aging (sun damage) • Chemical toxins • Cause • Decrease in collagen (inactive fibroblasts) • Increase in proteolytic activity due to collagenase

  44. Hypodermis

  45. Subcutaneous tissue

  46. Clinical Application

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