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Presentation Spring 2004 medivir.se

Presentation Spring 2004 www.medivir.se. Medivir in brief. One of the world leaders in polymerase research. Aiming for a similar position in protease research. Unique competitive advantages in all clinical projects. Nine partnerships with eight companies and a broad

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Presentation Spring 2004 medivir.se

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  1. Presentation Spring 2004 www.medivir.se

  2. Medivir in brief • One of the world leaders in polymerase research. • Aiming for a similar position in protease research. • Unique competitive advantagesin all clinical projects. • Nine partnerships with eight companies and a broad • network with academia in Europe and US. • Nordic marketing rights for all projects. • Located in Stockholm (Sweden) and Cambridge (UK) with • approximately 100 employees in R&D.

  3. Focused know-how base gives a variety of options Labial herpes Shingels Alzheimer Rheumatoid arthritis Know-how in polymerases & proteases Pain Multiple sclerosis Osteoporosis HIV Bacterial infections Asthma COPD Hepatitis

  4. Medivir: the strategic journey 2003 200X Pharma 200x • Polymerase and protease inhibitorsin clinical • development • Aim for product swaps in coming partnerships. • First product launch from own pipeline. • Research based pharmaceutical company with a • sales force focusing on specialist products for • the Nordic region. • Polymerase inhibitors in clinical development • and protease inhibitors in pre clinical research. • Research based biotech company. • Broad range of partnerships. • Nordic marketing rights to all projects. • Approximately 120 employees.

  5. Unique Selling Propositions in all clinical projects • Valomaciclovir (RP 606) - shingles - Expected to reduce Post-herpetic neuralgia • ME 609 – labial herpes -Expected to prevent ulcerative lesions • Alovudine (MIV 310) - HIV-NRTI • - Excellent activity against multiresistant strains • - Once daily dosing • MIV 210 – HIV-NRTI • - Excellent activity against multiresistant strains • - High oral bioavailability

  6. Medivir’s pipeline Discovery Lead Optimisation Preclinical IND Phase I Phase II Phase III NDA Market identification phase development RP-606 Shingles ME-609 Labial herpes MIV-310 NRTI Multiresistant HIV MIV-210 NRTI Multiresistant HIV MIV-150 HIV-NNRTI Population Council MV026048 HIV-NNRTI (Roche has an opt in) Cathepsin S RA, MS, Pain Cathepsin K Osteoporosis MIV-170 HIV-NNRTI HCV HCV Hepatitis Polymerase inhibitor Polymerase inhibitor combination Alzheimer Protease inhibitor Other Discovery activities in protease and polymerase

  7. Balancing risk Five individual projects in clinical development RP-606 Shingles ME-609 Labial herpes MIV-310 NRTI Multiresistent HIV MIV-210 Total deal value > 2.000m SEK MIV-150 Population Council Partners in four clinical projects MV026048 Cath S Three Joint Ventures Cath K Five individualprojects able to generate royalty MIV-170 HCV Four individual projects able to generate milestones HCV Alzheimer

  8. High Market Potential* Even if there isn't any drug preventing labial or genital herpes, sales amounted to more than 500m USD in 2002 Sales of shingles drugs > 1.000m USD in 2002. None of the existing drugs have a claim for PHN RP-606 ME-609 MIV-310 MIV-210 MIV-150 Sales of HIV drugs amounted to 5.300m USD in 2002. NRTI’s represented 60% and are expected to grow their market share above 70% in the coming five years. Population Council MV026048 MIV-170 Growing share of multiresistant HIV. MIV-310 and 210 are developed to address this. Cath S Cath K HCV HCV Alzheimer * Market data accrding to IMS-data

  9. The Late Stage Preclinical Pipeline Discovery Lead Optimisation Late preclinical IND Phase I Phase II Phase III NDA Market identification phase development MV026048 A new treatment paradigm for RA, MS and asthma. Possible improvements over TNF-alpha blockers. Cath S Cath K MIV-170 HCV HCV New treatment paradigm for osteoporosis and osteoarthritis. Present therapies like, bisphosphonates and HRT all have limitations Alzheimer Strong presence in hepatitis C Polymerase inhibitor Protease inhibitor

  10. Financial status 31th of December 2003 • Result after financial items amounted to till SEK -40,3 (-59,8 )m. • SEK 250m in cash. • Net R&D costs for 2004 will be approximately SEK 175m, this is in line with previous years. • The Q1 report will be published on the 22 April. • AGM will be held on the 22 April.

  11. Medivir’s 15 largest shareholders • Listed on • Attract-40 • Free float: 90% • 5.100 Shareholders • Market value: • 1.100m SEK

  12. Pharma World leader in drugs inhibiting proteases and polymerases

  13. www.medivir.se

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