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Enantioselective, Palladium-Catalyzed α-Arylation of N-Boc-pyrrolidine

Enantioselective, Palladium-Catalyzed α-Arylation of N-Boc-pyrrolidine. Kevin R. Campos J. Am. Chem. Soc. 2006 , 128 , 3538-3539. 2-Arylpyrrolidines. Biologically active compounds as neuronal nicotinic acetylcholine receptor. Effective controllers in asymmetric synthesis.

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Enantioselective, Palladium-Catalyzed α-Arylation of N-Boc-pyrrolidine

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  1. Enantioselective, Palladium-Catalyzed α-Arylation of N-Boc-pyrrolidine Kevin R. Campos J. Am. Chem. Soc.2006, 128, 3538-3539

  2. 2-Arylpyrrolidines Biologically active compounds as neuronal nicotinic acetylcholine receptor. Effective controllers in asymmetric synthesis.

  3. Conclusions • The enantioselective deprotonation/transmetalation/Negishi coupling was found to be quite general, affording a diverse array of 2-arylpyrrolidines in good yield and 96:4 er. • This sequence offers a number of advantages over existing methods and represents the most convenient and practical synthesis of enantiomerically enriched 2-arylpyrrolidines and 2,5-diarylpyrrolidines.

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