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Evaluation of charged particle induced reaction cross section data for the production of 87 Y

Evaluation of charged particle induced reaction cross section data for the production of 87 Y. Haleema Zainab Department of Physics Govt. College University, Lahore. Layout. Introduction Experimental technique Evaluation methodology Results. Applications of radioisotopes. Industry

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Evaluation of charged particle induced reaction cross section data for the production of 87 Y

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  1. Evaluation of charged particle induced reaction cross section data for the production of 87Y Haleema Zainab Department of Physics Govt. College University, Lahore

  2. Layout • Introduction • Experimental technique • Evaluation methodology • Results

  3. Applications of radioisotopes • Industry • Environment • Archeology • Agriculture • Earth sciences • Space sciences • Research activities

  4. Radioisotopes in medicine Nuclear Medicine It is a well established branch of medicine that used radioisotopes for diagnosis and treatment of disease. • Diagnostic applications • Therapeutic applications • Theranostic applications Objectives: Imaging: minimum dose (γ or β+ emitters) Therapy: suitable localised dose (βˉ or α-particle emitters)

  5. Applications of 87Y • 87Y (T1/2: 79.8 h; EC: 99.8%; Eγ: 388.5 keV (82.2%) and Eγ: 484.8 keV (89.8%)) • Gamma rays can be detected by planar or SPECT gamma camera with high-energy, high-resolution collimators. • The feasibility analysis of using 87Y as a tracer for in vivo imaging of 90Y-labeled antibodies has been performed by Sgouros (1998). Sgouros, G. 1998. Yttrium-90 biodistribution by yttrium-87 imaging: a theoretical feasibility analysis. Med. Phys. 25(8), 1487-90.

  6. Applications of 87Y (Contd..) • Kutzner et al (1992) shows that a good quality scan can be obtained by using 87Y, that allows the kinetic assessment of the 90Y labeled citrate in the treatment of metastatic bone lesions. • 87Y is used as parent radionuclide for making 87Y/87mSr generator. Kutzner, J., Hahn, K., Beyer, G.J., Grimm, W., Bockisch, A., Rosler, H.P., 1992. Scintigraphic use of 87Y during 90Y therapy of bone metastases. Nuklearmedizin. 31, 53–56.

  7. Importance of nuclear data Choice of a radionuclide depends on decay data • Suitability for imaging • Suitability for therapy Major references • NuDat • NNDC • Table of radioactive isotopes Optimisation of production procedure depends on reaction data • Maximise product yield • Minimise radioactive impurity level Major references • EXFOR

  8. Nuclear reactions

  9. Experimental Technique….

  10. Stack foil activation technique

  11. Stack design First stacks • Energy: 50-25 MeV • Target: natZr (25µm) • Monitor: natTi, natFe (25µm) • Degrader: Aluminum • Beam current: 100nA • Time of irradiation: 20 min Second stack • Energy: 30-0 MeV • Target: natZr (25µm) • Monitor: natTi, natNi (25µm) • Degrader: Aluminum • Beam current: 100nA • Time of irradiation: 20 min

  12. Stack design

  13. Steps for stack preparation • Cutting of foil (25×25mm) • Measurement of dimensions and weight • Cleaning of foils • Wrapping of foils in Kapton tape • Labeling of foils • Mounting on frame

  14. Beam size verification Beam size and position was verified prior to actual irradiation by • Phosphors plate • Irradiatation of Gafchromic films

  15. Gamma spectroscopy Spectroscopy • HPGedetector coupled to PC based analyzer MestroOrtec. Efficiency & energy calibration • 152Eu, 137Cs, 56Co and 133Ba Peak fitting • Radware

  16. Activation formula • λ : Decay constant of radionuclide (S-1) • C : Counts under peak area of desired radionuclide • ε : Efficiency of HPGe detector • Iγ : Intensity of gamma line or branching ratio • tm : Spectrum acquision or measurement time (S) • ti : Itrradiation time (S) • tc : Cooling time (S) • n : Number of particles in target (#/cm2) • φ : Beam flux (S-1)

  17. Beam energy measurement • Anderson & Ziegler (A&Z) formalisms SRIM code • Spectroscopic data from monitor foils

  18. Beam energy measurement Activation of natTi foil produces 48V and 46Sc by reactions natTi(d,x)48V and natTi(d,x)46Sc φ1=φ2 n1=n2

  19. Calculation of beam Intensity

  20. Evaluation methodology….

  21. Evaluation methodology • Charged particle data evaluation methodology is developing, mainly co-ordinated by IAEA. It involves • Compilation of data (EXFOR) • Normalisation of data (decay data, monitor cross section, etc.) • Nuclear model calculation (ALICE-IPPE, TALYS, EMPIRE ) • Statistical fitting of data • Role of nuclear model calculations • Validation of experimental data • Guidance in rejection of inaccurate data • Prediction of unknown data

  22. Results Production routes of 87Y

  23. Thank You

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