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Early Onset of Schizophrenia Spectrum Disorder

Early Onset of Schizophrenia Spectrum Disorder. Premorbid history. Language abnormalities. Social impairment. Attention problems. Schizophrenia Biologic Etiology. Neuropathology in structure, function, and neurotransmitters, especially in temporal and frontal regions. Genetic diathesis.

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Early Onset of Schizophrenia Spectrum Disorder

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  1. Early Onset of Schizophrenia Spectrum Disorder • Premorbid history • Language abnormalities • Social impairment • Attention problems

  2. Schizophrenia Biologic Etiology • Neuropathology in structure, function, and neurotransmitters, especially in temporal and frontal regions • Genetic diathesis • Intra uterine stress • Neurocognitive impairment • Language impairment

  3. Schizophrenia Psychosocial Etiology • Communication deviance • Life events and stress

  4. Schizophrenia Differential Diagnosis • Bipolar Disorder • ADHD • Conduct Disorder • PTSD • PDD

  5. Schizophrenia Prognosis • Poor - early onset, neurologic abnormalities, negative symptoms • Good - higher IQ, precipitant

  6. Psychopharmacology for Children and Adolescents • Stimulants • Antidepressants • Mood stabilizers

  7. Psychopharmacology for Children and Adolescents (Cont’d) • Neuroleptics • Adrenergic agonists • Minor tranquilizers

  8. Attention Deficit Disorder Decision Tree Impulsivity Inattention Methylphenidate bupropion clonidine tricyclic SSRI Dextroamphetamine Combinations Mood Stabilizers Buspar Beta blockers

  9. Stimulants • Methylphenidate (Ritalin) • Dextroamphetamine (Dexedrine) • Adderall • Magnesium pemoline (Cylert)

  10. Antidepressants for ADHD • Fluoxetine (Prozac) • Bupropion (Wellbutrin) • Venlafaxine (Effexor) • Tricyclics

  11. Other Treatments for ADHD • Alpha-adrenergic stimulating agents • Beta-adrenergic blocking agents

  12. Depression Decision Tree Noradrenergic Serotoninergic Bupropion Venlafaxine Remeron Stimulants B-blockers SSRI BuSpar Valproate Carbamazepine Lithium

  13. Treatment of Psychosis • Atypical neuroleptics • Risperidone • Olanzapine • Quetiapine • Mood stabilizers • Valproate • Lithium • Carbamazepine

  14. “Ideally, one would like to practice medicine without having to bother with actual patients.”

  15. Other Treatment Modalities for Neurodevelopmental Disorders • Social skills training • Stress management • Cognitive-Behavioral Treatment (CBT) • School Accommodation • Specialized neuropsychological approaches • Family structure and support • Psychotherapy

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