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Milsana ® Fungicide Nick Macris Director, Business Development nmacris@marroneorganics.com (727) 742-2571 (mobile) (530

Milsana ® Fungicide Nick Macris Director, Business Development nmacris@marroneorganics.com (727) 742-2571 (mobile) (530) 750-2800 (office) www.marroneorganics.com. Milsana ® Fungicide Overview. Source: Extract from giant knotweed Reynoutria sachalinensis ( REYSA ).

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Milsana ® Fungicide Nick Macris Director, Business Development nmacris@marroneorganics.com (727) 742-2571 (mobile) (530

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  1. Milsana® Fungicide Nick MacrisDirector, Business Development nmacris@marroneorganics.com (727) 742-2571 (mobile) (530) 750-2800 (office) www.marroneorganics.com

  2. Milsana® Fungicide Overview • Source: Extract from giant knotweed Reynoutriasachalinensis (REYSA). • Target pathogens: Milsana® effectively controls powdery mildew, gray mold, rust, and bacterial blight on ornamental plants and edible crops. • Mode of Action: Induction of plant defense responses. • Reactive oxygen species • Enzymes of the phenolic pathway • Lignification of cell walls • Papilla formation • Phytoalexins • Has EPA crop and non crop registrations as biochemical biopesticide. California - non crop label only.

  3. Milsana® Label Recommendations • Apply at the rate of 0.5-1.0% in 50 to 100 gallons of water per acre. • Add 0.02% wetting agent such as Nu-Film P. • Use the spray mixture preventatively at the 4-6 leaf plant stage and repeat spraying every 7-14 days depending on disease pressure.

  4. Milsana® on Ornamentals • Begonias • Lisianthus • Salvias • Crape myrtle • Petunias • Snapdragons • Freesias • Poinsettias • Zinnias • Gerbera • Roses Diseases Powdery Mildew (Oidium spp) Gray Mold (Botrytis cinerea) Rust (Puccinia antirrhini)

  5. Milsana® on Food Crops • Cucumbers • Melons • Squash • Grapes • Peppers * • Strawberries • Lettuce • Pumpkins • Tomatoes Diseases Powdery Mildew (Sphaerotheca spp, Erysiphe cichoracearum ) Gray Mold (Botrytis cinerea) Bacterial blight (Xanthomonas campestris)*

  6. Summary of Milsana® Activity

  7. Field Data Grape powdery mildew trial, (W.D. Gubler, Univ. of California, Davis, July 2000)

  8. Field Data Botrytis disease ratings and yield of “Trust” Tomatoes (Central Mississippi Research Center, 2003) Treatment Disease Marketable yield rating per plant (lb) (0-100%) Untreated Control 53.3 a 9.6 a Milsana® 26.7 b 11.4 b Elevate® 50WG 16.7 b 11.2 b Switch® 62.5 WG 26.7 b 11.4 b Serenade® 20.0 b 10.7 a Scala® 53.3 a 10.7 a

  9. Regulatory/Toxicology • Current EPA registration for crop and non crop (ornamentals) uses. • CA non crop label only (MOI will submit crop label by the end of 2007). • More targets will be added (e.g. tomato, turf). • All other crops and diseases are opportunities for IR-4 priorities. • MOI is working on an organic formulation.

  10. Potential IR-4 Projects • Test Milsana®as part of IPM programs in ornamentals, vegetables, fruit, vines (Botrytis, mildews, bacterial diseases. Other diseases ? • Test Milsana® on turf diseases. • Test efficacy against other pathogens, such as oomycetes (Phytophthora spp. and downy mildew).

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