The UK Opportunity: what is experimental medicine?

1. UNLOCK YOUR GLOBAL BUSINESS POTENTIAL • The UK Opportunity: what is experimental medicine? Late stage clinical trials Experimental medicine

2. UNLOCK YOUR GLOBAL BUSINESS POTENTIAL The UK offers your company access to: • The UK Opportunity: Globally Competitive 1. • Translational research expertise with world – renowned KOLs Unrivalled data and well-characterised patient cohorts 2. 3. Leading translational research facilities co-located within the hospital setting

3. UNLOCK YOUR GLOBAL BUSINESS POTENTIAL • The UK research ecosystem supports innovation flow from discovery science through to evidence generation and uptake Medical Research Council and medical research charities. Research funding focused on the mechanisms of health and disease Translational Research Centres Translating biological discovery into the clinical setting Translational Research Centres including NIHR Biomedical Research Centres and Units, Translational Research Partnerships (TRPs) and Collaborations (TRCs) UK Clinical Research Facilities and Experimental Cancer Medicine Centres Expertly delivering early stage patient studies Clinical Research Networks Embedded in the NHS supporting the delivery of multicentre clinical studies UK Health data In the UK, your business will have access to unrivalled, clinically-coded health data and bio- repositories

4. Understand disease biology Deliver engineering and informatics solutions Develop novel targets for drug discovery Text comes here The UK can help your business.. Identify patient cohorts Discover and validate biomarkers Text comes Develop sensing and diagnostic technologies UNLOCK YOUR GLOBAL BUSINESS POTENTIAL • The UK has the visionary science, centres of academic and clinical excellence, key opinion leaders, experienced partners, and the tools to help your business • The UK is home to world-class discovery science.. • The Medical Research Council • The WellcomeTrust • Cancer Research UK and Cancer Research Technology

5. Conduct biomarker-led approaches to patient stratification Conduct fast and efficient experimental research Develop and test new therapeutic targets Text comes here Access to patient samples and biobanks Access well characterised cohorts of patients Text comes here Access state of the art technology platforms UNLOCK YOUR GLOBAL BUSINESS POTENTIAL • The UK is home to world-class translational research infrastructure that works in partnership with industry • ..with translational research expertise and infrastructure to take your innovation from discovery to the clinic • NIHR Translational Research Partnerships • NIHR Biomedical Research Centres and Units • Scotland Leading academic centres of excellence in drug discovery and experimental medicine • Wales & NI provide industry with leading experimental medicine centres within leading hospital partnerships. The UK can help your business..

6. Speed up the flow of innovation from bench to bedside Connect to world-leading principal investigators Connect to expert research nurses experienced at running early stage trials Text comes here Quickly identify the right centres of excellence for a particular study Design and deliver complex clinical studies Text comes here Conduct cost-effective and smarter clinical research UNLOCK YOUR GLOBAL BUSINESS POTENTIAL • UK Clinical Research Faculties support inpatient and outpatient clinical research studies across a wide range of disciplines, led by investigators in both adult and paediatric specialities • Expert clinical research facilities support inpatient and outpatient clinical research • UK Clinical Research Facilities for Experimental Medicine • UK Experimental Cancer Medicine Centres The UK can help your business..

7. Get advice on compatibility of protocols with current UK clinical practice Access GCP trained nurses to support patient recruitment Rapidly set up multi-site studies Text comes here The UK can help your business.. Speed up costing and contracting at sites Identify the right sites drawing on more than 1000 primed investigators Text comes here Trouble shoot support from inside the NHS to keep study on track UNLOCK YOUR GLOBAL BUSINESS POTENTIAL • Clinical Research Networks provide infrastructure to support clinical research in the NHS, giving patients access to high quality research studies and supporting the Life-Sciences Industry to develop potential new treatments • Experimental research can be rapidly and efficiently translated to extensive late stage clinical research networks across the UK • NIHR Clinical Research Network in England • Scotlandhas clinical research networks in Diabetes, Dementia and Cancer. • Through the Northern Ireland Clinical Research Network and Health Research Wales, your business can be connected to expertise and networks to conduct late stage clinical research in these regions

8. UNLOCK YOUR GLOBAL BUSINESS POTENTIAL • In the UK, your business will have access to stable unrivalled, clinically-coded health data and bio- repositories. • …supported by a single health system with unrivalled, clinically-coded health data to drive delivery of clinical research More than 60 million people are served by a National Health System • Example data resources: • UK Biobank • The Scottish Health Informatics Programme (SHIP) • NIHR BioResource • Clinical Practice Research Datalink (CPRD) “We have had a very productive relationship with the Cambridge Bioresource (CBR) over the last two to three years where collaboration has resulted in provision of genetic resource, conduct of clinical and translational trials, and publication of both clinical and immuno-inflammatory mechanistic study results related to pharmacogenetic interactions. The initial interactions between us (industry) and CBR have been very successful and this is a collaboration we are keen to maintain and develop.” Simon McHugh, Director of Scientific Operations at GlaxoSmithKline