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Alzheimer’s of Central Alabama June 2014 Gene Regulation in Alzheimer’s Disease J. David Sweatt

Alzheimer’s of Central Alabama June 2014 Gene Regulation in Alzheimer’s Disease J. David Sweatt Dept of Neurobiology McKnight Brain Institute UAB School of Medicine. Research Conducted at the McKNIGHT BRAIN INSTITUTE at UAB. McKnight Brain Institute.

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Alzheimer’s of Central Alabama June 2014 Gene Regulation in Alzheimer’s Disease J. David Sweatt

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  1. Alzheimer’s of Central Alabama June 2014 Gene Regulation in Alzheimer’s Disease J. David Sweatt Dept of Neurobiology McKnight Brain Institute UAB School of Medicine

  2. Research Conducted at the McKNIGHT BRAIN INSTITUTE at UAB

  3. McKnight Brain Institute Approximately $ 12,000,000 Total Annual Research Funding (NIH, NSF, DoD, Private Foundations) Neurobiology Department Ranked in the Top 20 Nationally in NIH Funding 30 Investigators; 60,000 ft2 lab and office space NIH Training Grant in Cognition and Cognitive Disorders

  4. The Molecular Basis of Memory

  5. Genes Have A 3-Dimensional Structure

  6. Can We Regulate Gene StructureTo Improve Memory? Histone Acetyltransferase (HAT) Histone Deacetylase (HDAC) Trichostatin A or Sodium Butyrate

  7. Can We Regulate Gene StructureTo Improve Memory?

  8. Testing Long-term Memory Formation in Mice Train !@#$ Test Context + Shock Oh No! Freezing Behavior

  9. Does HDAC Inhibition Enhance Memory Formation? Train !@#$ Test Context + Shock Oh No! Freezing Behavior

  10. Fear Conditioning

  11. Gene Engineering – Making a Mouse with Alzheimer’s Disease

  12. Can HDAC Inhibitors Ameliorate AD-related Memory Dysfunction? Train !@#$ Test Context + Shock Oh No! Freezing Behavior

  13. The Molecular Basis of Long-term Memory • Epigenetic mechanisms are involved in memory formation • Manipulating the epigenome may provide a new avenue for ameliorating aging-related memory loss

  14. Acknowledgements: Dee Shirley and Jennifer Green Evelyn F. McKnight Foundation Civitan International Hillcrest Foundation US National Institutes of Health UAB & UAB School of Medicine

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