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A Goat on Bald Mountain Case 05-1829

A Goat on Bald Mountain Case 05-1829. Thomas E. Cecere North Carolina State University. Signalment/History. Castrated male adult mixed-breed goat Complete shed in spring for past several years – hair regrows over the summer Most recent episode – no hair regrowth

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A Goat on Bald Mountain Case 05-1829

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  1. A Goat on Bald MountainCase 05-1829 Thomas E. Cecere North Carolina State University Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  2. Signalment/History • Castrated male adult mixed-breed goat • Complete shed in spring for past several years – hair regrows over the summer • Most recent episode – no hair regrowth • Progressive ptyalism starting in spring Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  3. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  4. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  5. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  6. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  7. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  8. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  9. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  10. Morphologic Diagnosis Salivary gland: Diffuse, severe lymphocytic and eosinophilic sialoadenitis with atrophy and interstitial fibrosis Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  11. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  12. Thymoma associated diseases • Dry mouth (Sjogren Syndrome), alopecia areata, myesthenia gravis and others in humans • Sjogren Syndrome • Keratoconjunctivitis sicca, xerostomia • Immune-mediated destruction of lacrimal and salivary gland • Primary vs. secondary (rheumatoid arthritis, SLE, polymyositis, scleroderma, thymoma) • Xerostomia vs. Ptyalism in this case? Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  13. Alopecia Areata • Autoimmune skin disease • Non-scarring alopecia • Lymphocytic targeting of anagen hair bulbs • Associated with thymoma in humans • Alopecia Universalis • Thymoma associated exfoliative dermatitis • Cats, rabbits • Lymphocytic mural folliculitis Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only Rottenberg S et al. Thymoma-associated exfoliative dermatitis in cats. Vet Pathol. 2004 Jul;41(4):429-33.

  14. Acknowledgements • Keith Linder • Kristi Mozzachio • NCSU Histology Lab – Sandra Horton • Arnaud, Arun, Danielle, Crystal, Midori, Sally Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

  15. Questions? Questions? Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

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