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The Placebo Drift Debate in Antidepressant Clinical Trials

The Placebo Drift Debate in Antidepressant Clinical Trials. Zach Daniel White Biology 101h- Desaix. Why does it matter?.

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The Placebo Drift Debate in Antidepressant Clinical Trials

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  1. The Placebo Drift Debate in Antidepressant Clinical Trials Zach Daniel White Biology 101h- Desaix

  2. Why does it matter? “An antidepressant that brought relief to only seventy percent [of patients] would be a valuable treatment if it did so in one week and had few side effects. Unfortunately, given the current clinical trial methods and placebo-response rates, such an antidepressant, regardless of its true efficiency, would not have more than a fifty percent chance of looking better than placebo” -Dr. Arif Khan and Dr. Walter Brown

  3. The Placebo Drift Debate

  4. Conditioning argument “You’ve learned over the course of your life that going to the doctor, being examined, having him write out a prescription, waiting in line at the pharmacy, taking a pill, [these things] are generally followed by some benefit. So you’ve learned a pattern of reacting that seems to be pretty powerful” -Dr. Arthur Barsky-

  5. The severity of depression changes on placebo drift

  6. HAM-D Scores (13-22) Low Moderate Depression (23-25) High Moderate Depression (26-28) Moderately Severe Depression (29-35) Severe Depression

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