1 / 8

Is the ACL degenerated before rupture?

Is the ACL degenerated before rupture?. John Magne Hoseth, M.D. Kristiansund Hospital. ACL injuries. Incidence - approximately 1 per 3000 individuals Predominantly in a young and sports-active population Five times higher in females.

feliciab
Télécharger la présentation

Is the ACL degenerated before rupture?

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Is the ACL degenerated before rupture? John Magne Hoseth, M.D. Kristiansund Hospital

  2. ACL injuries • Incidence - approximately 1 per 3000 individuals • Predominantly in a young and sports-active population • Five times higher in females. • Rate of posttraumatic osteoarthritis is unchanged after ACL reconstruction (Maguire et al 09)

  3. Tendon vs Ligament • Almost identical anatomy • Collagen fiber bundles arranged into fascicles, with variable amounts of elastic fibers (Wheater`s 93) • ACL – biomechanically acts the same way as tendons

  4. Degeneration in tendons • Chronic degenerative changes in tendons predispose to rupture (Kannus et al 91) • Eccentric excercise increases synthesis of type I collagen in achilles tendinosis (Langberg et al 05)

  5. Aims of study To examine whether there is an underlying degenerative process in the ACL prior to rupture

  6. Methods • Biopsy study • Histopathological analysis

  7. Biopsy study • By explorative arthroscopy within 24 hours on patients presenting with traumatic hemarthrosis • Reduces arthrofibrosis • Shortens rehabilitation time before a possible reconstructive procedure • Removal of the ACL if ruptured

  8. Histopathology • Samples are fixed in 70 % ethanol, dehydrated and paraffin embedded • Investigation of angiofibroblastic change. A reparative process that is a strong indicator of chronic degeneration • Apoptosis starts immediately after ACL rupture • Uncertain if findings related to apoptosis can be attributed to pre-rupture ( A. Scott )

More Related