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Select each stage to learn more.

Select each stage to learn more. Stage I. Stage II. Stage IV. Stage III. Additional Information. Stage I. Disease is located in a single lymph node region or a single extranodal organ. Extranodal organ refers to any organ outside of the lymphatic system, for example the lungs.

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Select each stage to learn more.

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  1. Select each stage to learn more. Stage I Stage II Stage IV Stage III Additional Information

  2. Stage I • Disease is located in a single lymph node region or a single extranodal organ. Extranodal organ refers to any organ outside of the lymphatic system, for example the lungs. Lymph node Diaphragm

  3. Stage II • Disease is present in 2 distinct locations, both affected areas are on the same side (above or below) of the diaphragm. The affected locations may be 2 distinct nodal regions or one nodal region and one extranodal organ. Lymph node Diaphragm

  4. Stage III • Disease is present on both sides of the diaphragm and may involve both nodes and extranodal organ(s). Lymph node Diaphragm

  5. Stage IV • Diffuse or disseminated involvement of one or more extralymphatic organs, including any involvement of the liver, bone marrow, or nodular involvement of the lungs. Lymph node Diaphragm Liver Bone marrow

  6. Additional Information • Following allocation of a stage, certain letters are added to signify additional useful information about the disease: • The letter B is appended to the stage if the patient has a fever >100.4°F, night sweats, or loss of at least 10% of body weight in the 6 months prior to diagnosis (eg, stage IIB). These symptoms are commonly referred to as B symptoms. If these symptoms are absent, the letter A is appended, (eg, stage IIA). • If tissues close to, but distinct from the major lymphatic regions are affected, the letter E, (for extranodal) is appended to the stage, (eg, stage IIIE). • If the spleen is involved, the letter S is appended to the stage, (eg, stage IIE or IIES). • If bulky disease is present, the letter X is appended to the stage, (eg, stage IIIX). Bulky disease in MCL is typically defined as disease >10 cm in diameter, or other indications of high disease burden such as high LDH, and lymphocytosis.

  7. Based on the information in his chart, what stage is SJ’s MCL? Select his stage from the options below. [ ] Stage IA [ ] Stage IB [ ] Stage IIE SJ [ ] Stage IIB Evidence of spleen, liver, and bone marrow involvement; confirmed with subsequent tests. [ ] Stage IIS [ ] Stage IIIE Fever, night sweats, and weight loss [ ] Stage IVA Involved lymph nodes in neck, left armpit, and groin [X] Stage IVB

  8. What is SJ’s MIPI score and prognostic group? SJ 67 years old ECOG: 1 [ ] Low risk [ ] 0 Serum LDH: 4.3 x ULN WBC: 17.2 x 109/L [ ] Intermediate risk [ ] 5 [X] High risk [X] 8

  9. Using the MIPI scale, determine the patient’s risk group. 55 years old ECOG score: 1 LDH: 0.75 x ULN WBC: 12.5 x 109/L The patient’s MIPI score is: <---------> Based on this, the patient’s risk group is: <------------------------>

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