SEMINAR

1. SEMINAR 1. Title : Formation and Characterization of Nanoparticle Bioconjugates for Biochip Application 2. Speaker :Dr.Tai Hwan Ha (KOREA RESEARCH INSTITUTE OF BIOSCIENCE& BIOTECHNOLOGY) 3. Time : 16:00 – 17:00, Thursday, Oct. 16, 2008 4. Place : e+ Lecture Hall (room 83188), 2nd Research Building, Sungkyunkwan University 5. Summary : It is a critical and essential process in the fabrication of innovative biochip and biosensor applications to devise bioconjugates of inorganic nanomaterials with conventional biomaterials such as proteins or nucleotides, and to understand their underlining physicochemistry. For instance, in an attempt to fabricate a large scale antibody microarrays, protein-G layers can be anchored in advance on gold surface to directionally immobilize antibodies of interest. In doing so, we manufactured a novel GST-tagged protein G analogs through genetic engineering and synthesized its counter ligand, GST-specific one, and their affinity for antibodies were compared with other conventional methods. As another example of promising bioconjugates, polyarginine tagged enzymes are tethered onto carboxylated gold nanoparticles , and the enzymatic behavior at the interface will be addressed. Finally, as the other partners for the inorganic bioconjugates, shape controlled syntheses of gold nanomaterials will be briefly addressed. 6 Background : Surface Chemistry, FT-IR spectroscopy, Electrochemistry Education 1995 Department of Chemistry, Seoul National University, B.S 1998 School of Chemistry, Seoul National University, M.S 2002 School of Chemistry, Seoul National University, Ph.D Work Experience 2002 – 2003 Post.doc BK21 Division of Chemistry and Molecular Engineering 2003 - Senior Research Scientist, KRIBB 2007 Visiting Scholar, Department of Chemistry, CALTECH 7. Questions : Professor Sung Ha Park (☏ 031-299-4544)