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Dean’s Workshop on Biomedical Engineering

Dean’s Workshop on Biomedical Engineering. Biomedical Engineering at Yale: Collaborations and Translational Partnerships W. Mark Saltzman. Where did we come from? Who are we now? Where do we want to be? My perspective on today’s program. Groundwork.

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Dean’s Workshop on Biomedical Engineering

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  1. Dean’s Workshop on Biomedical Engineering Biomedical Engineering at Yale: Collaborations and Translational Partnerships W. Mark Saltzman

  2. Where did we come from? Who are we now? Where do we want to be? My perspective on today’s program

  3. Groundwork Prior to 1996: Separate faculty research activity 1996-99: Whitaker Foundation Special Opportunity Award 1996: Program in BME formed Foundation 1999: First full class of B.S. BME graduates 1999-2000: Provost/ Dean of Medicine task force on BME; President Levin allocates 6 new BME faculty positions 2000: PhD Specialization in BME approved by Graduate School Growth 2001-2002: Mark Saltzman and Erin Lavik hired to develop biomolecular engineering effort 2002: Bioimaging faculty secure $7M Image-Guided Neurosurgery Grant (first out of new NIH- NIBIB institute) 2003: Department of BME officially begins 2004: Richard Carson and Michael Levene hired to lead molecular imaging effort 2005: Tarek Fahmy hired to bridge drug delivery/molecular imaging

  4. Where did we come from? Who are we now? Where do we want to be? My perspective on today’s program

  5. Biomedical Engineering at Yale:Research and Educational Strengths Biomolecular engineering Bioimaging Biomechanics

  6. Richard Carson, PET imaging and modeling Todd Constable, MR imaging James Duncan, Image analysis/processing Fahmeed Hyder, MR spectroscopy Michael Levene, Biophotonics/optical microscopyDouglas Rothman, MR spectroscopy Lawrence Staib, Image analysis/processing Steven Zucker, Computer vision Jacek Cholewicki, Spine biomechanics Tarek Fahmy, Targeted drug delivery Erin Lavik, Tissue engineering Mark Saltzman, Drug delivery/tissue engineering

  7. Hemant Tagare, Diagnostic Radiology Xenios Papademetris, Diagnostic Radiology Robin deGraaf, Diagnostic Radiology Steven Segal, Physiology/Pierce Themis Kyriakides , Pathology Fred Sigworth, Physiology Mark Laubach, Neurobiology/Pierce Laura Niklason, Anesthesiology Francesco d’Errico, Diagnostic Radiology

  8. e.g. Molecular imaging e.g. In vivo tissue function e.g. Functional tissue engineering Biomedical Engineering at Yale:Research and Educational Strengths Biomolecular engineering Bioimaging Biomechanics

  9. Where did we come from? Who are we now? Where do we want to be? My perspective on today’s program

  10. Where did we come from? Who are we now? Where do we want to be? My perspective on today’s program

  11. #1 Imaging is central to Biomedical Engineering research

  12. fMRI MRS Biomedical Imaging at Yale

  13. Image-guided neurosurgery for epilepsy Jim Duncan, Dennis Spencer et al. fMRI Left hand (red/yellow) & right hand (blue) motor cortex activation MRS

  14. Liver Ovary Lung Breast Multiphoton in situ histology, Michael Levene

  15. Francesco d’Errico, Dept Diagnostic Radiology Microemulsions for ultrasound-controlled drug release Concept of image-guided drug release with ultrasound sensitive microemulsions Doppler imaging of rabbit kidney whereby the vaporization of droplets in the renal artery reduces the blood flow Perflurocarbon droplets with oil inclusions containing a water-insoluble drug The blood flow is gradually restored when bubbles dissolve in the blood-stream

  16. #2 Biomolecular Engineering provides new opportunities for basic and translational research

  17. Nanoparticles for Controlled Release of CurcuminMargaret Cartiera, Mark Saltzman, Marie Egan, Michael Caplan

  18. Nanoparticles: particles as small as a virus, but engineered from safe synthetic polymers and loaded with high concentrations of drugs

  19. Microengineered Scaffolds to Guide Cell Development to Tissues

  20. #3 Collaboration and translation

  21. One biomedical engineer’s experience at Yale

  22. Opening Remarks Carolyn W. Slayman, Ph.D. Deputy Dean for Academic and Scientific Affairs 1:30-2:00 PM BIOMEDICAL ENGINEERING AT YALE: COLLABORATIONS AND TRANSLATIONAL PARTNERSHIPS W. Mark Saltzman, Ph.D. Goizueta Foundation Professor of Chemical and Biomedical Engineering and of Cellular and Molecular Physiology 2:00-2:30 PM TOWARDS THE CONSTRUCTION OF NEW GENERATION VACCINE SYSTEMS BASED ON BIOLOGICAL-DRIVEN DESIGNS Tarek Fahmy, Ph.D. Assistant Professor of Biomedical Engineering Ira S. Mellman, Ph.D. Sterling Professor of Cell Biology and Professor of Immunobiology 2:30-3:00 PM BRINGING MULTIPHOTON MICROSCOPY TO THE CLINIC: ASSESSMENT OF WOUND HEALING WITH ARTIFICIAL SKIN GRAFTS AND OTHER APPLICATIONS Michael J. Levene, Ph.D. Assistant Professor of Biomedical Engineering Jordan S. Pober, M.D., Ph.D. Professor of Pathology, Immunobiology and Dermatology 3:00-3:30 PM ARCHITECTURAL HYDROGELS: SCAFFOLDS FOR VASCULAR AND NEURAL PROGENITOR CELL CONSTRUCTS FOR THE NERVOUS SYSTEM Erin Lavik, Sc.D. Assistant Professor of Biomedical Engineering Joseph A. Madri, M.D., Ph.D. Professor of Pathology and of Molecular, Cellular and Developmental Biology

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