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Influenza Vaccine Responses

Influenza Vaccine Responses. Roland A. Levandowski, M.D. Division of Viral Products. Prepared for Vaccines and Related Biological Products Advisory Committee 18-19 February 2004. Serum Panels for Serologies. 1. ALAN HAMPSON ADULT A/NEW CALEDONIA/20/99-LIKE (H1N1)

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Influenza Vaccine Responses

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  1. Influenza Vaccine Responses Roland A. Levandowski, M.D. Division of Viral Products Prepared for Vaccines and Related Biological Products Advisory Committee 18-19 February 2004

  2. Serum Panels for Serologies • 1. ALAN HAMPSON ADULT A/NEW CALEDONIA/20/99-LIKE (H1N1) • WHO, AUSTRALIA ELDER A/PANAMA/2007/99 (H3N2) • B/SHANGDONG/07/97 • 2. JOHN WOOD, PH.D ADULT A/NEW CALEDONIA/20/99 (H1N1) • NIBSC, ENGLAND ELDER A/PANAMA/2007/99 (H3N2) • B/SHANGDONG/7/97 • 3. TAKATO ODIGARI, PH.D. ADULT A/NEW CALEDONIA/20/99-LIKE (H1N1) • WHO, JAPAN ELDER A/PANAMA/2007/99-LIKE (H3N2) • B/HONG KONG/330/01-LIKE

  3. Serum Panels for Serologies • 4. STEFAN GRAVENSTEIN, M.D. ADULT A/NEW CALEDONIA/20/99 (H1N1) • EASTERN VIRGINIA ELDER A/PANAMA/2007/99 (H3N2) • MEDICAL SCHOOL CHILD B/HONG KONG/1434/2002 • 5. CHRISTINE TURLEY, M.D. CHILD A/NEW CALEDONIA/20/99 (H1N1) • UTMB A/PANAMA/2007/99 (H3N2) • GALVESTON, TEXAS B/HONG KONG/1434/2002 •  6. STEFAN GRAVENSTEIN, M.D. ADULT B/VICTORIA/504/2000 ELDER(VACCINE USED IN 2001-02) • 7. JOHN WOOD, PH.D ADULT B/JOHANNESBURG/5/99 • (VACCINE USED IN 2001-02)

  4. ANTIGENS FOR SEROLOGIES (H1) VACCINE STRAIN A/NEW CALEDONIA/20/99 (H1N1) REPRESENTATIVE CURRENT STRAINS A/DAKAR/85/2003 (H1N1) A/MINNESOTA/18/2003 (H1N1) A/NAGANO/1328/2003 (H1N1) A/BELEM/84066/03 (H1N2) A/ICELAND/123/2003 (H1N2) A/PERU/2223/2003 (H1N2) A/VIRGINIA/20/03 (H1N2)

  5. HI ANTIBODY RESPONSES TO THE H1 COMPONENT2003-2004 INFLUENZA VACCINEADULT POPULATION (CDC)

  6. HI ANTIBODY RESPONSES TO THE H1 COMPONENT2003-2004 INFLUENZA VACCINEELDERLY POPULATION (NIBSC)

  7. HI ANTIBODY RESPONSES TO THE H1 COMPONENT2003-2004 INFLUENZA VACCINEPEDIATRIC POPULATION (CDC AND CBER)

  8. A/NEW CALEDONIA/20/99-LIKE VACCINESSUMMARY TABLEVIRUSES WITH > 50% GMT REDUCTION

  9. ANTIGENS FOR SEROLOGIES (H3) VACCINE STRAIN A/PANAMA/2007/99 REPRESENTATIVE CURRENT STRAINS A/CHILE/82660/2003 A/AICHI/205/2003* A/KUMAMOTO/102/2002* A/FUJIAN/445/2003* A/NAGASAKI/152/2003* * = FUJIAN/411-LIKE A/TEXAS/40/2003* A/TEXAS/141/2003* A/WYOMING/03/2003* A/HONG KONG/1186/2002*

  10. HI ANTIBODY RESPONSES TO THE H3 COMPONENT2003-2004 INFLUENZA VACCINEADULT POPULATION ( AUS )

  11. HI ANTIBODY RESPONSES TO THE H3 COMPONENT2003-2004 INFLUENZA VACCINEELDERLY POPULATION (CDC)

  12. HI ANTIBODY RESPONSES TO THE H3 COMPONENT2003-2004 INFLUENZA VACCINEPEDIATRIC POPULATION (CDC AND CBER)

  13. A/PANAMA/2007/99-LIKE VACCINESSUMMARY TABLEVIRUSES WITH > 50% GMT REDUCTION

  14. ANTIGENS FOR SEROLOGIES (B) VACCINE STRAIN CURRENT VACCINE OLDER VACCINE B/SHANGDONG/7/97+ B/JOHANNESBURG/5/99 B/HONG KONG/1434/2002+ B/VICTORIA/504/2000 REPRESENTATIVE CURRENT STRAINS B/SICHUAN/259/2003+ B/BADEN-WURTENBURG/26/2002* B/SHAHGHAI/361/2002* B/JIANGSU/10/2003* + = HONG KONG/330-LIKE B/JILIN/20/2003* * = SHANGHAI/361-LIKE B/MALAYSIA/879/2003* B/WASHINGTON/3/2003*

  15. HI ANTIBODY RESPONSES TO THE B COMPONENT2003-2004 INFLUENZA VACCINEADULT POPULATION (NIBSC)

  16. HI ANTIBODY RESPONSES TO THE B COMPONENT2003-2004 INFLUENZA VACCINEELDERLY POPULATION (CDC)

  17. HI ANTIBODY RESPONSES TO THE B COMPONENT2003-2004 INFLUENZA VACCINEPEDIATRIC POPULATION (CDC AND CBER)

  18. HI ANTIBODY RESPONSES TO THE B COMPONENT2001-2002 INFLUENZA VACCINEADULT AND ELDERLY (NIBSC AND CBER)

  19. B/HONG KONG/330/2001-LIKE VACCINESSUMMARY TABLEVIRUSES WITH > 50% GMT REDUCTION

  20. Influenza Vaccine ResponsesSummary Studies with sera collected after immunization with current vaccines show that: • Representative influenza A (H1N1) and (H1N2) viruses are well-inhibited • Many a/Fujian/411/2002 (H3N2)-like viruses are less well inhibited than the the vaccine strain • B/Hong Kong/330/2001-like viruses are well inhibited but B/Shanghai/361/2002 and similar viruses are less well inhibited than the vaccine strains

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