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Cancer Lesson 3.2 - P art 2

Cancer Lesson 3.2 - P art 2. How do normal cells become cancer cells?. Do now. What kind of mutations can affect cancer genes? How do they occur?. Mutating important cancer genes. Inserting transposons Rearranging large segments of chromosomes Mutating individual nucleotides.

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Cancer Lesson 3.2 - P art 2

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  1. Cancer Lesson 3.2- Part 2 How do normal cells become cancer cells?

  2. Do now • What kind of mutations can affect cancer genes? • How do they occur?

  3. Mutating important cancer genes • Inserting transposons • Rearranging large segments of chromosomes • Mutating individual nucleotides Proto-oncogenes Tumor suppressors

  4. Why SNPs are important in cancer • Some SNPs are known to cause inherited cancer (OMIM database). • Some SNPs have been associated with cancer but not yet proven (FLAGGED SNP database).

  5. Substituion mutations Mutations that do change the amino acid are called non- synonymous Mutations that don’t change the amino acid are called synonymous

  6. Flagged SNP Color Code • Doesn’t affect protein (synonymous) • Does affect protein (non-synonymous) • In an intron or untranslated region

  7. Activity • Do the worksheet from this lesson that examines the roles of mutations in important oncogenes and tumor suppressors in cancers.

  8. Wrap Up

  9. Switching off tumor suppressors Tumor suppressor  p53 DNA Damage Cell cycle arrest   Tumor suppressor Apoptosis Tumor suppressor

  10. Switching on proto-oncogenes Oncogenes Oncogenes Oncogenes Oncogenes Cell cycle Arrest Apoptosis Cell cycle Arrest Apoptosis Cell cycle Arrest Apoptosis Cell cycle Arrest Apoptosis     p53 DNA Damage  Tumor suppressor Hyperproliferation!

  11. Both the brake and the gas pedal are mutated in cancer Normal proto-oncogene Tumor suppressor Normal cell Oncogene 1st mutation Mutated tumor suppressors 2ndmutation CANCER!

  12. Homework • Read the workbook for lesson 3.2 and answer the questions

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