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Pertussis

Pertussis. There has been an outbreak of Pertussis on the northeastern coast of the US. Thousands of people have so far been infected. General Information. Pertussis is commonly called Whooping Cough It is a highly contagious bacterial disease caused by Bordetella Pertussis

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Pertussis

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  1. Pertussis There has been an outbreak of Pertussis on the northeastern coast of the US. Thousands of people have so far been infected.

  2. General Information • Pertussis is commonly called Whooping Cough • It is a highly contagious bacterial disease caused by Bordetella Pertussis • In some countries, it is called the 100 days’ Cough or Cough of 100 Days • Symptoms usually begin mild and develop into severe coughing fits, which produce the namesake, high pitched “whoop” sound. • Coughing stage lasts approximately six weeks before subsiding. • Prevention by vaccination is necessary because of the seriousness of the disease in children. • Antibiotics are of little direct benefit, but they shorten the duration of infectiousness.

  3. Symptoms • Paroxysmal cough • Inspiratory whoop • Fainting or vomiting after coughing • Coughing can cause.. • Subconjunctival hemorrhages • Rib fractures • Post-cough fainting • Vertebral artery dissection • Violent coughing can cause the Pleura to rupture, and can lead to a pneumothorax

  4. Diagnosis • Throat Cultures • The doctor will take a throat swab to test for the infection. They then put the swab in a cup (cultures) and allow the possible infection to grow and develop. • Polymerase Chain Reaction (PCR) • A biochemical technology to amplify one or a few pieces of DNA across several different magnitudes, generating thousands to millions of copies of the DNA sequence • Relies on thermal cycling—constant cycles of repeated heating and cooling for DNA melting • Direct Immunofluorescence • Uses one antibody that is attached to a fluorophore. The antibody links itself to the targeted molecule and the fluorophore can be located by microscopy.

  5. Prevention • Vaccination • Usually administered through a type of DTP vaccination (diphtheria-tetanus-pertussis) • Antibiotics • Erythromycin, the antimicrobial of choice for treatment or postexposure prophylaxis of pertussis

  6. Possible Treatments • There aren’t any direct cures, but antibiotics can be administered to shorten the duration of the disease. • Home Remedies include… • Cough Drops • Tea

  7. Sources • http://en.wikipedia.org/wiki/Pertussis • http://en.wikipedia.org/wiki/Pertussis_vaccine • http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5414a1.htm • http://www.cdc.gov/pertussis/clinical/treatment.html

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