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Process design for the production of Fab fragment for therapy

Process design for the production of Fab fragment for therapy. Group 6 Shiang -Yuan Hsieh, Yun-Hsuan Liu, Chao-Ming Yen. Antibody therapy. Bevacizumab v.s Ranibizumab. Anti- angiogenic drugs: block the formation of new blood v essels to inhibit tumor growth

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Process design for the production of Fab fragment for therapy

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  1. Process design for the production of Fab fragment for therapy Group 6 Shiang-Yuan Hsieh, Yun-Hsuan Liu, Chao-Ming Yen

  2. Antibody therapy

  3. Bevacizumabv.sRanibizumab • Anti-angiogenic drugs: block the formation of new blood vessels to inhibit tumor growth • By targeting and inhibiting the function of a natural protein called vascular endothelial growth factor (VEGF) • The whole antibody versus a antibody fragment

  4. Antibody • Also called immunoglobulins (Ig) that used by immune system. • Five classes of Ig: IgA, IgE, IgG, IgD, IgM.

  5. Fragment antigen binding(Fab fragment) • A region on an antibody which binds to antigens • Composed of one constant and one variable domain of each of the heavy and the light chain

  6. Why make Fab Fragments? • Smaller size that can promote the efficiency of penetration of tissue section. • Reduce nonspecific binding that results from Fc interactions. • Potentially higher sensitivity in antigen. • Reduce the risks from immune response. • Production is more economical.

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