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General Pathology: Introduction to the Course

General Pathology: Introduction to the Course. Lorne Holland, M.D. Lorne.Holland@ucdenver.edu. General Information. COURSE DIRECTOR: Lorne Holland, M.D. Leprino Office Building, Main Laboratory- Rm 280 Email: Lorne.Holland@ucdenver.edu Office: (720) 848-7050

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General Pathology: Introduction to the Course

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  1. General Pathology:Introduction to the Course Lorne Holland, M.D. Lorne.Holland@ucdenver.edu

  2. General Information COURSE DIRECTOR: Lorne Holland, M.D. Leprino Office Building, Main Laboratory- Rm 280 Email: Lorne.Holland@ucdenver.edu Office: (720) 848-7050 ADMINISTRATIVE COORDINATOR: Jaime Kean Building A01 Room L15-2203 Email: Jamie.Kean@ucdenver.edu Phone (303) 724-3905

  3. Map Leprino Office Building Parking Garage

  4. Exams • Sample questions will periodically be posted on Blackboard with answers following shortly • Before each exam there will be a Q&A session • This is an opportunity for you to ask questions about the material • This is not meant to be a formal review of all lecture material • For best responses, please send me your question(s) a day or two in advance so I know what to expect

  5. Exams • Multiple-choice, single best answer • 2-3 questions per lecture • Mid-October and December 17th • 2nd exam is cumulative with approximately 80% new and 20% old • Exams will be timed with 1.5 minutes allotted for each question

  6. Exams • How much does a normal human head weigh? • More than twice the average orange • Between 4.4 and 5.3 kilograms • Hair is typically 0.2% to 1.1% of head weight • It would weigh only 1/6th as much on the moon

  7. Exams • Review session immediately after • Answers will be projected • Your chance to ask questions • Only opportunity to review test answers

  8. Exams • Grading • Tests are sent to the computer center for grading where they calculate statistics for each question • A few questions will have “bad” numbers and will be thrown out • Too hard or too easy • Random answer pattern

  9. Other Tests • Independent study questions • Posted on Blackboard and due Sept 28th • May collaborate, but each student must submit their own answers • Remember, this material is fair game for both exams • Periodic, unannounced quizzes • Multiple-choice, single best answer and/or short answer • You can use class notes and textbook • Students not present when the quizzes are handed out will receive a zero • Lowest quiz score will be dropped

  10. Objectives • Each lecture will have a set of objectives • This is the bare minimum you should be getting out of each lecture • If you can not perform the objectives then it is unlikely you will pass • If you only know material specifically addressed by the objectives, you will probably pass, but only barely (70-80%)

  11. Odds and Ends • Lecture handouts should be available on Blackboard 48 hrs before lecture • Exam dates will be firm, but lectures may occasionally move around a bit. You should have at least 24 hrs warning. • Please address questions directly to the lecturer. If you do not receive a response within 48 hrs then let me know • Evaluations after each test. Please complete them so I know what is working and what is not

  12. Scope of Pathology Pathology Clinical Anatomic Experimental “laboratory medicine”

  13. Scope of Pathology Pathology Clinical Anatomic Experimental Pathogenesis Etiology Epidemiology

  14. Scope of Pathology Pathology Clinical Anatomic Experimental Surgical Gross / Micro Gross / Micro Autopsy Microscopic Cytology Microscopic Hematopath

  15. Scope of Pathology Pathology Clinical Anatomic Experimental Chemistry Urinalysis Hematology Serology Microbiology Virology Molecular T.D.M. Toxicology Coagulation Transf. Med Point of Care Flow Cytometry

  16. Quick Guide to Microscopy • Unless otherwise stated, pictures in books and lecture and hemotoxylin and eosin (H&E) • Proteins and starch stain pink • Nucleic acids (DNA, RNA) stain blue • Air, water, sugar and lipids do not stain at all • Naturally colored materials, black, brown, green

  17. Quick Guide to Microscopy

  18. Quick Guide to Microscopy

  19. Other Colors • Golden (yellow/brown/green) • Bile • Brown • Hemosiderin, lipofuschin (iron) • Black • Carbon • Melanin

  20. Special Stains • PAS  starch/sugar • Prussian Blue  iron • Oil Red O  lipids

  21. Immunohistochemistry • Produce antibodies to specific molecules, usually proteins • Attach a marker of some kind to the antibody • Wash a tissue section with the labeled antibody

  22. Estrogen receptor- Breast cancer Keratin- Carcinoma, not lymphoma Alphafetoprotein- Testicular Cancer CD15/30- Hodgkin Lymphoma

  23. Questions?

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