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González Blanca M.N. Gámez Daniel M.D. Salinas Ricardo M.D. Ortiz Xochitl PhD .

Universidad Autónoma de Nuevo León Hospital Universitario Dr. José E. González” Servicio de Geriatría. “BMI, Albumin, Hemoglobin and Alzheimer’s Disease”. González Blanca M.N. Gámez Daniel M.D. Salinas Ricardo M.D. Ortiz Xochitl PhD.

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González Blanca M.N. Gámez Daniel M.D. Salinas Ricardo M.D. Ortiz Xochitl PhD .

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  1. Universidad Autónoma de Nuevo León Hospital Universitario Dr. José E. González” Servicio de Geriatría “BMI, Albumin, Hemoglobin and Alzheimer’s Disease” González Blanca M.N. Gámez Daniel M.D. Salinas Ricardo M.D. Ortiz Xochitl PhD. Presented : onJuly 8th 2009 IAGG Congress Paris 2009 Introduction: Studies had shown a decline in serum albumin levels in patients with Alzheimer’s disease. The objective of this study is to show the changes of the albumin and hemoglobin levels in 30 patients diagnosed with Alzheimer’s disease, during a one year period. Methods and materials: This is an observational, descriptive, prospective study. The sample consisted of 30 outpatients that fulfilled the DSM IV and NINDS-ADRDA diagnosis criteria for Alzheimer’s disease. Three visits were performed at 0, 6, and 12 months. Body mass index (BMI), albumin and hemoglobin (Hb) were evaluated using standard methods. Data analysis was performed using SPSS version 13 by means of a Pearson correlation with 0.95 confidence interval, mean study (t student) and Anova variable correlation. Results: The descriptive analysis showed: Sample population 30 patients, with means of age 77.90, of educational level 6.30, of Mini Mental State Examination (MMSE) score 12.83 (5-25). Statistical analysis demonstrated that there is no significant change in the levels of serum albumin and it’s independent of the cognitive decline, showing the following means: V1: 40.9, V2 41.2 and V3 41.3 (t: 64.5, 78.6, 70.8, .000 significance). The hemoglobin and BMI showed a decline during the disease process with the following means: Hb in V1 134.5, V2 132.1 and V3 127.0 (t: 52.9, 45.7, 33.3, .000 significance) and BMI mean: V1 25.1, V2 25.17 and V3 24.62 (t: 25.2, 23.8, 18.6 .000 significance). During the correlation study (Pearson), statistical differences were found in Alzheimer’s disease, BMI and Hb and no correlation could be determined with respect to the albumin level. Conclusion: The study showed that the albumin level did not decline during the Alzheimer’s disease process. Although a correlation between Alzheimer’s disease, BMI and Hemoglobin levels was found. We suggest new studies to develop clinical elements that can predict or participate as biological markers of Alzheimer’s disease. Referentes: 1.- Tae-Suk Kim, Chi-Un Pae, Su-Jung Yoon, Woo-Young Jang, NamJin Lee, Jung-Jin Kim, Soo-Jung Lee, Chul Lee, In-Ho Paik, Chang-Uk Lee. “Decreased plasma antioxidants in patients with Alzheimer's disease” 2006; International Journal of Geriatric Psychiatry; 21 (4). 2. Te-Pin Ng, Lei Feng, Mathew Nitiand Keng Bee Yap“Albumin, haemoglobin, BMI andcognitive performance in older adults” Age and Ageing, May 20 2008; 37(4):423-429.

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