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EPAC = Exchange Proteins Activated by cAMP Two isoforms : EPAC1 and EPAC2

Key Terms. EPAC = Exchange Proteins Activated by cAMP Two isoforms : EPAC1 and EPAC2 Previous evidence demonstrates deletion of both genes reduces glutamate release (Yang et al., 2012) . SUR1 = K ATP channel type-1 sulfonylurea receptor

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EPAC = Exchange Proteins Activated by cAMP Two isoforms : EPAC1 and EPAC2

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  1. Key Terms • EPAC = Exchange ProteinsActivated by cAMP • Twoisoforms: EPAC1 and EPAC2 • Previousevidencedemonstratesdeletion of bothgenes reduces glutamate release (Yang et al., 2012) . • SUR1 = KATPchannel type-1 sulfonylureareceptor • Kir6.1 = KATP channelsubunitassociateswith SUR1 • EPAC bindsspecifically to SUR1 receptorconsisting of aminoacids 859-881

  2. EPSCswereevoked by pair-pulsed stimulation of the mossyfibertracks in the hilus of the dentategyrus (CA3-CA3 synaptic inputs). Reording in the presence of 10μm BMI and 20μm NBQX at holding of +60mv

  3. Deletion of EPAC increaseschannel open probability:

  4. Results of Kainic Acid treatment in mice:

  5. Conclusions: • Geneticdeletion of EPAC genes or disruption of EPAC-SUR1 interaction increasesopeningprobability. • EPAC controls KATPchannelactivity via tonic inhibition of SUR1 receptor • Other EPAC variants have been found in Austism Spectrum Disorder Patients • Possible molecularmechanism

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