1 / 21

Increased risk for T. vaginalis in an urban population of young adults

Increased risk for T. vaginalis in an urban population of young adults. S M Rogers for MSSP Research Team. Monitoring STIs in the Population Research Team. Susan M Rogers, Research Triangle Institute Charles F Turner, City University of New York

helia
Télécharger la présentation

Increased risk for T. vaginalis in an urban population of young adults

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Increased risk for T. vaginalis in an urban population of young adults SM Rogers for MSSP Research Team

  2. Monitoring STIs in the Population Research Team • Susan M Rogers, Research Triangle Institute • Charles F Turner, City University of New York • Bill Miller, University of North Carolina, Chapel Hill • Emily Erbelding, Johns Hopkins Medical Institutions • Marcia Hobbs, University of North Carolina, Chapel Hill • Elizabeth Eggleston, Research Triangle Institute • Anthony Roman, University of Massachusetts • Sylvia Tan, Research Triangle Institute • James Chromy, Research Triangle Institute • Ravikiran Muvva, Baltimore City Health Department

  3. Trichomoniasis • Most common, curable sexually transmitted disease worldwide (WHO 2001, CDC) • Associated with increased risk for HIV, HSV-2, PID • Caused by motile protozoan, T. vaginalis • Variety of diagnostic tools available • MAY 2011: FDA approved PCR (Gen-Probe)

  4. Epidemiology of T. vaginalis • Current understanding largely limited to clinical settings and special populations • U.S. population assessments • 2001-04 NHANES • 2001-02 Add Health • Case reporting data not available in U.S.

  5. In general, epidemiological studies suggest T. vaginalis: • Is more common among women than men • Varies by race/ethnicity, age • Generally asymptomatic • Frequent co-morbidity with other STIs • Among population subgroups, TV prevalence exceeds that of other STIs, i.e., CT and GC

  6. Monitoring STIs in the Population (MSSP) Study Objectives • Assess prevalence of T. vaginalis and C. trachomatis among young adults, Baltimore, MD 2006-09 • Identify characteristics and behaviors associated with TV and CT infection • Compare trends in infection prevalence over time

  7. 2006-09 MSSP: Survey methods • Probability sample of 15-35 year-olds residing in Baltimore with land-line telephone • Telephone-ACASI on sexual behaviors and STI history • Mail-out, mail-back specimen collection, TMA testing for TV and APTIMA (Gen-Probe) for CT • Sampling weights derived

  8. 2006-09 MSSP: Results • 4,996 eligible households identified • Interviews completed with 2,936 (59%) • 1843 women, 1093 men • Mean age, 24.6 yrs. • 62.3% Black, 76.8% never married • 2,120 (73%) provided valid specimens for STI testing • Imputation for specimen non-response

  9. Estimated prevalence of TV and CT Prevalence

  10. Estimated prevalence of TV and CT infection • From bio-specimens alone TV 7.5% (6.0, 9.0) CT 3.9% (2.7, 5.0) • Bio-specimens plus imputations (MI of 5-2-2011) TV 7.6% (6.1, 9.0) CT 4.1% (2.9, 5.3)

  11. Estimated prevalence of T. vaginalis: sex and race

  12. Estimated prevalence of C. trachomatis:sex and race

  13. Estimated prevalence of TV and CT by age

  14. Estimated prevalence of T. vaginalis: age and sex

  15. Other Risk factors for TV and CT *Models control for age, sex, and race/ethnicity

  16. Trends in TV and CT, 2006-09

  17. Methodological considerations/lessons • Challenges of population-based studies • Expensive T-ACASI • Specimen collection Mail-out, mail-back • Representativeness/response rates • Increased use of cell phones, decrease in land-lines

  18. Methodological considerations/lessons • Specimen testing • Use of non-FDA approved test for TV diagnosis • Test performance in low prevalence population • Disclosure of research results

  19. Conclusions: 2006-09 MSSP • Epidemiology of T. vaginalis: • Higher prevalence of TV than CT • TV more common among women than men, particularly high among Black women (16.1%) • Substantial co-infection with CT • Prevalence of TV was consistently high across all age groups • Majority infections asymptomatic • Trend analysis: rates similar over period observed

  20. Implications of these results Routine screening for TV in conjunction with CT in populations at elevated risk of infection should be considered • Expand our understanding of TV epidemiology • Improve detection and enhance treatment to avoid health complications

  21. Research Support • NIH grant R01-HD047163 from the National Institute of Child Health and Human Development

More Related