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Tam ás Kiss, PhD (Wigner, Pfizer )

Tam ás Kiss, PhD (Wigner, Pfizer ) Conductance based modeling of hippocampal cellular and network activity McCulloch-Pitts–level modeling of hippocampal function Analysis of electrophysiological data sets Pharmaco-behavioral experimentation with rodents

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Tam ás Kiss, PhD (Wigner, Pfizer )

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  1. Tamás Kiss, PhD (Wigner, Pfizer) • Conductance based modeling of hippocampal cellular and network activity • McCulloch-Pitts–level modeling of hippocampal function • Analysis of electrophysiological data sets • Pharmaco-behavioral experimentation with rodents • Interested in the normal and pathological information processing in the hippocampo-cortico-thalamic network during wakefulness and sleep.

  2. Accumulation of Aβ might cause: • Hyperexcitability due to neural depolariztion caused by membrane permeabilzation • Pathological single-cell rhythms resulting from changing the activity of various (L-type Ca2+, A-type K+, IK, ICT, etc.) ion channels • Network instability following complex modulation of synaptic transmission • Decreased network activity due to cell death Hypothesis: changing levels of amyloid-β modulate hippocampal network activity in a nonlinear fashion via affecting synaptic and non-synaptic cellular elements. This can be modeled in a computer and used to understand drug mechanism of action and predict efficacy. Aβ–related non-linear decrease of hippocampal θ power in transgenic mice. From Scott et al., Neurobiol of Aging, 2012.

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