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a. b. 0.1. 1.0. 10.0. 0.1. 1.0. 10.0. 28.4. 73.9. 72.5. 30. 100. 62.0. 74.7. 80. 22.1. Fold luciferase (RLU) -512/+72LMP1 promoter. 60. Fold luciferase (RLU) -512/+72LMP1 promoter. 20. 32.2. 40. 26.9. 10.2. 20. 1. 10. 5.5. 0. 4.0. 3.7. E2. E3C. 1.0. 0.9.

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32.2

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  1. a. b. 0.1 1.0 10.0 0.1 1.0 10.0 28.4 73.9 72.5 30 100 62.0 74.7 80 22.1 Fold luciferase (RLU) -512/+72LMP1 promoter 60 Fold luciferase (RLU) -512/+72LMP1 promoter 20 32.2 40 26.9 10.2 20 1 10 5.5 0 4.0 3.7 E2 E3C 1.0 0.9 Gadd34 180-610 Gadd34 180-483 (2 mg ) E2 Gadd34 FL (1-674) E3C (0.1 mg) Gadd34 555-558 KVRFKARA Gadd34 180-483 Gadd34 612-616 DRARA Gadd34 FL (1-674) c. 16.0 12.9 14.0 12.0 10.0 Fold luciferase (RLU) -512/+72LMP1 promoter 6.4 8.0 4.7 6.0 4.0 1.0 1.0 1.2 2.0 0.0 E2 (2mg) E3C (0.1mg) FGadd34 180-483 (0.1mg) FGadd34 180-610 (0.1 mg) 0 0 FL E2 E3C

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