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ORGANELLA SEL

ORGANELLA SEL. Agustina Setiawati , M.Sc., Apt. A mile of journey begin with one small step. Ribosom. Pabrik untuk sintesis protein Dibangun dari molekul2 protein & rRNA

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ORGANELLA SEL

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  1. ORGANELLA SEL AgustinaSetiawati, M.Sc., Apt A mile of journey begin with one small step

  2. Ribosom • Pabrikuntuksintesis protein • Dibangundari molekul2 protein & rRNA • Pd selprokariot, ribosomtdptbebasdlmsitosol, dlmseleukariotribosomtdptbebasdisitosol, matriksmitokondria, stromakloroplas, ataumenempel pd permukaanselaput RE • RE kasaradalah RE ygdilekatibnykribosom, RE halustidakmengandungribosom

  3. Ribosom • Ribosomterdiridari sub unit yang tidaksama • Ukuranribosomditentukan dg analisissedimentasi dg mengukurlajupengendapandlmlarutankental (missukrosa) dg pemusingankecepatantinggi. • Koefisiensedimentasiditentukan dg S (Svedberg)  namapenemu ultracentrifuge • Ribosomprokariotmemilikikoefisiensedimentasi 70S, ribosomeukariotmemilikikoefisiensedimentasi 80S

  4. Ribosom

  5. Ribosom • Ribosom prokariot tdr atas sub unit besar 50S & sub unit kecil 30S • Ribosom eukariot tdr atas sub unit besar 60S & sub unit kecil 40S • Ribosom mitokondria & kloroplas juga tdr atas 2 sub unit. Ribosom mitokondria bervariasi dr ukuran 55S pd hewan sampai 80S pd bbrp protozoa & jamur. Ribosom kloroplas adalah 70S pd semua sel hijau

  6. Karakteristik ribosom sitoplasma (* rRNA pd subunit 60S hwn adl 28S, sementara pd tanaman, jamur & protista adl 25-26S)

  7. Ribosom organel

  8. Ribosom • Peranan ribosom dlm sintesis protein : • Sub unit kecil mengikat mRNA & tRNA • Sub unit besar berperan dlm pbtk ikatan peptida

  9. RETIKULUM ENDOPLASMA Membran yang bertumpuk yang terdapatantaramembranseldaninti

  10. RE KASAR DAN HALUS

  11. RE HALUS (SMOOTH RE) Fungsi: 1. Sintesis lipid 2. Metabolismekarbohidrat 3. Metabolismetoksindanobat

  12. Transport vesiclebuds off 4 Ribosome Secretory(glyco-) proteininside transportvesicle Sugarchain 3 Glycoprotein 1 2 ROUGH ER Polypeptide RE KASAR (ROUGH RE) Fungsi: 1. Sintesis protein 2. Menyusunmembransel

  13. Badan Golgi 5-8 kantungmembranbbtkmangkuk ( cistenae ) dg ujungmenggelembung & menempelsatusama lain.

  14. Badan Golgi • Sintesismakromolekul • Distribusidanlalulintasprodukkimiasel • Modifikasi protein dan lipid

  15. Badan Golgi Badangolgiberbentuk polar Bagiancis, tempat protein masukdanbagian trans, tempat protein keluar Terbagimenjadikompartemen/ruang yang berbedadenganenzimygspesifik Jumlahtiapselberbedatergantungjenisdanfungsisel

  16. LISOSOM Organellauntukpencernaanmakromolekul (protein, asamnukleat) Pencernaandilakukansecarafagositosis Mempunyaiberbagaienzimhidrolase

  17. DigestiolehLisosom

  18. EnzimLisosom • 50 different degradative enzymes • Acid hydrolases • Active at pH 5 (inside lysosome) • Inactive if released into cytosol (pH 7.2) • Acidic pH of lysosomes maintained by a proton pump in the lysosomal membrane • Requires ATP  mitochondria

  19. DefisiensiEnzimLisosom

  20. PEROKSISOM • Similar structure to lysosomes • Single membrane • Consume oxygen • but not to form ATP as mitochondria • Degrades hydrogen peroxide (H2O2) • can be toxic to cells • Using catalase to degrade hydrogen peroxide to water Crystalline inclusion

  21. Any question?

  22. TERIMA KASIH

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