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ACKNOWLEDGMENTS:

THE REGISTRY OF THE INTERNATIONAL SOCIETY FOR HEART AND LUNG TRANSPLANTATION: EIGHTEENTH ANNUAL REPORT. We wish to extend our sincere thanks to the many thoracic transplant surgeons, physicians and data coordinators in transplant programs throughout the world whose timely

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ACKNOWLEDGMENTS:

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  1. THE REGISTRY OF THE INTERNATIONAL SOCIETY FOR HEART AND LUNG TRANSPLANTATION: EIGHTEENTH ANNUAL REPORT

  2. We wish to extend our sincere thanks to the many thoracic transplant surgeons, physicians and data coordinators in transplant programs throughout the world whose timely and accurate submission of data has made these analyses possible. ACKNOWLEDGMENTS:

  3. REGISTRY DATABASE

  4. REGISTRY DATABASE

  5. % donors 50-55 % donors 50+ 12% HEART TRANSPLANTATION 9% Percent of Donors by Age Number of Transplants * 6% 3% * * Numbers may be low due to incomplete reporting.

  6. AGE DISTRIBUTIONOF HEART RECIPIENTS (1982-2000) % of Transplants

  7. INDICATIONS ADULT HEART TRANSPLANTATION

  8. AGE DISTRIBUTION OF PEDIATRIC HEART RECIPIENTS 386 374 375 365 363 362 352 347 346 326 332 255 194 Number of Transplants 128 111 75 42 11 9

  9. < 1 Year 1-10 Years 11-17 Years PEDIATRIC HEART TRANSPLANTATIONINDICATIONS BY AGE (1982-1999)

  10. HEART TRANSPLANTATION ACTUARIAL SURVIVAL(1982-2000) Half-life =9.1 years Conditional Half-life = 11.6 years N=52,195

  11. ADULT HEART TRANSPLANTATIONACTUARIAL SURVIVAL Survival (%) All comparisons with 1980-1987 are significant at p < 0.0001

  12. ADULT HEART RE-TRANSPLANTATION(1982-1999) 1 Year Patient Survival (%)

  13. ADULT HEART TRANSPLANTATIONRISK FACTORS FOR 1 YEAR MORTALITY N=38,943

  14. ADULT HEART TRANSPLANTATIONRISK FACTORS FOR 1 YEAR MORTALITY * * Latest period in cohort N=38,943

  15. ADULT HEART TRANSPLANTATIONRISK FACTORS FOR 1 YEAR MORTALITY N=38,943

  16. ADULT HEART TRANSPLANTATIONRISK FACTORS FOR 1 YEAR MORTALITY N=38,943

  17. ADULT HEART TRANSPLANTATIONRISK FACTORS FOR 1 YEAR MORTALITY N=38,943

  18. ADULT HEART TRANSPLANTATIONRISK FACTORS FOR 5 YEAR MORTALITY N=26,250

  19. ADULT HEART TRANSPLANTATIONRISK FACTORS FOR 5 YEAR MORTALITY N=26,250

  20. ADULT HEART TRANSPLANTATIONRISK FACTORS FOR 5 YEAR MORTALITY N=26,250

  21. ADULT HEART TRANSPLANTATIONRISK FACTORS FOR 5 YEAR MORTALITY N=26,250

  22. PEDIATRIC HEART TRANSPLANTATIONACTUARIAL SURVIVAL (1982-2000) All comparisons with <1 year significant at p < 0.0001

  23. PEDIATRIC HEART TRANSPLANTATIONRISK FACTORS FOR 1 YEAR MORTALITY * * Earliest period in cohort N=3,760

  24. PEDIATRIC HEART TRANSPLANTATIONRISK FACTORS FOR 1 YEAR MORTALITY N=3,760

  25. PEDIATRIC HEART TRANSPLANTATIONRISK FACTORS FOR 5 YEAR MORTALITY * * Latest year in cohort N=2,465

  26. PEDIATRIC HEART TRANSPLANTATIONRISK FACTORS FOR 5 YEAR MORTALITY N=2,465

  27. PEDIATRIC HEART TRANSPLANTATIONRISK FACTORS FOR 5 YEAR MORTALITY N=2,465

  28. FUNCTIONAL STATUS Heart (April 1994-Dec. 2000)

  29. EMPLOYMENT STATUS Heart (US Data: April 1994-Dec. 2000)

  30. REHOSPITALIZATION POST HEARTTRANSPLANTATION(April 1994 - Dec. 2000)

  31. HEART TRANSPLANT MAINTENANCEIMMUNOSUPPRESSION % of Patients

  32. HEART TRANSPLANTATIONDonor age versus Ejection Fraction yr 1 to yr 2

  33. POST-HEART TRANSPLANT MORBIDITY(April 1994-December 2000)

  34. ADULT HEART TRANSPLANTATIONRISK FACTORS FOR CAV WITHIN 3 YEARS N=7,691

  35. ADULT HEART TRANSPLANTATIONRISK FACTORS FOR CAV WITHIN 3 YEARS N=7,691

  36. MALIGNANCY POST-HEART TRANSPLANTATION(April 1994-December 2000) 1-Year Followup 5-Year Followup

  37. HEART TRANSPLANTS: CAUSE OF DEATH(1982-2000) Cause of Death (%) Timing of Death

  38. HEART-LUNG TRANSPLANTATION

  39. ADULT HEART-LUNG TRANSPLANTATIONINDICATIONS (1982-2000)

  40. HEART-LUNG TRANSPLANTATIONACTUARIAL SURVIVAL (1982-2000) Half-life = 2.8 years Conditional Half-life = 8.2 years N=2,550 Survival (%)

  41. 1412 1386 1385 1331 1325 1284 LUNG TRANSPLANTATION 1176 1062 887 Mean Donor Age 675 404 184 74 38 7 4

  42. AGE DISTRIBUTION OF LUNG TRANSPLANTATION

  43. ADULT LUNG TRANSPLANTATIONINDICATIONS (1983-2000) SingleLung Bilateral/Double Lung

  44. 85 86 80 PEDIATRIC LUNG TRANSPLANTATIONAGE DISTRIBUTION (1986-2000) 68 64 65 50 47 45 Number of Transplants 41 19 6 3 4 1

  45. PEDIATRIC LUNG TRANSPLANTATIONINDICATIONS (1986-2000)

  46. LUNG TRANSPLANTATIONACTUARIAL SURVIVAL(1983-2000) Double lung: 1/2-life = 4.5 Years; Conditional 1/2-life = 7.9 Years Single lung: 1/2-life = 3.6 Years; Conditional 1/2-life = 5.7 Years All lungs: 1/2-life = 3.8 Years; Conditional 1/2-life = 6.3 Years

  47. ADULT LUNG TRANSPLANTATIONACTUARIAL SURVIVAL(1988-2000) Comparison of 1988-1992 vs. 1997-2000 was significant at p = 0.002

  48. PEDIATRIC LUNG/HRT-LUNG TRANSPLANTATIONACTUARIAL SURVIVAL(1984-2000)

  49. ADULT LUNG TRANSPLANTATIONRISK FACTORS FOR 1 YEAR MORTALITY * * Earliest period in cohort N=9,653

  50. ADULT LUNG TRANSPLANTATIONRISK FACTORS FOR 1 YEAR MORTALITY N=9,653

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