1 / 34

Neoplasia VI

Neoplasia VI. DR OSAMA I NASSIF MD,FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY KAUH. Etiology of cancer. Chemical carcinogens. Radiation carcinogenesis. Viral oncogenesis. Biology of tumor growth. Kinetics of tumor cell growth. Tumor angiogenesis.

imelda
Télécharger la présentation

Neoplasia VI

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Neoplasia VI DR OSAMA I NASSIF MD,FRCPC CONSULTANT & ASSOCIATE PROFESSOR DEPARTMENT OF PATHOLOGY KAUH

  2. Etiology of cancer. • Chemical carcinogens. • Radiation carcinogenesis. • Viral oncogenesis.

  3. Biology of tumor growth. • Kinetics of tumor cell growth. • Tumor angiogenesis. • Tumor progression and heterogeneity. • Tumor invasion and spread.

  4. Kinetics Of Tumor Cell Growth • Doubling time : equal or more than that of normal cells. • Growth fraction : cells in replicative pool , rarely >20%. • Production vz loss :

  5. Tumor Angiogenesis • Tumor-associated angiogenic factors : -bFGF , VEGF……etc. • Macrophage derived growth factors: -TNF-α. • Weak angiogenic inhibitors: -Angiostatin , thrombospondin ( p53 upregulated) .

  6. Kinetics Of Tumor Cell Growth Clinical implications: 1- cancer therapey: Targeting cycling cells. Effect of radiation & debulking. 2- latent period of tumors : Months to years.

  7. Tumor Progression and Heterogeneity.

  8. Tumor Invasion and Spread. • Methods of spread : - Direct. -Through blood vessels. -Through lymph vessels.

  9. Etiology of Cancer. • Chemical carcinogens. • Radiation carcinogenesis. • Viral oncogenesis.

  10. Chemical Carcinogens.

  11. Chemical Carcinogens.

  12. Chemical Carcinogens

  13. Chemical Carcinogens

  14. Chemical Carcinogens

  15. Chemical Carcinogens

  16. Chemical Carcinogens

  17. Chemotherapy Induced Malignancies

More Related