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NON-CATECHOLAMINES

NON-CATECHOLAMINES. Selective α 1 agonists: Phenylephrine & methoxamine Powerful direct stimulants of α 1 -receptors  v.c . of b.v .   PVR. They  B.P. with reflex bradycardia (this effect is more prolonged than that of NE). Metabolized by MAO, but not by COMT.

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NON-CATECHOLAMINES

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  1. NON-CATECHOLAMINES

  2. Selective α1 agonists: • Phenylephrine & methoxamine • Powerful direct stimulants of α1-receptors  v.c. of b.v.  PVR. • They  B.P. with reflex bradycardia (this effect is more prolonged than that of NE). • Metabolized by MAO, but not by COMT. • Methoxamine has a longer duration of action.

  3. Uses: • Locally: nasal and ocular decongestant to treat rhinitis and conjunctivitis. • Maintenance of B.P. during surgery. • Treatment of hypotension caused by excessive doses of vasodilators or drug induced shock.

  4. Midodrine: • A prodrug that is enzymatically hydrolyzed to desglymidodrine (α1 agonist) • Uses: treatment of postural hypotension. • Oxymetazoline (specific α2a agonist) & Xylometazoline: • Uses: topical decongestants because of their ability to promote v.c. of the nasal mucosa.

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