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PhD Position … for a nicer smile …

PhD Position … for a nicer smile … Glycoprofiling of the oral pathogen Tannerella forsythia for identifying novel strategies in pathogenicity. Dep. of NanoBiotechnology NanoGlycobiology Group. Time schedule: Start: March-May 2012; Duration: 3 years. Short summary of project

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PhD Position … for a nicer smile …

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  1. PhD Position … for a nicer smile … Glycoprofiling of the oral pathogenTannerella forsythia for identifying novel strategies in pathogenicity Dep. of NanoBiotechnology NanoGlycobiology Group Time schedule:Start: March-May 2012; Duration: 3 years Short summary of project The Gram-negative oral anaerobe T. forsythia is crucially involved in the onset of periodontitis, a multifactorial destructive gum disease that is the major cause of tooth loss. Consequently, there is a great biomedical interest in understanding the bacterium-host cross-talk, for which especially the bacterial cell surface is of high relevance. Based on the recent identification of a general protein O-glycosylation system in T. forsythia that contributes to the formation of a unique “sweet” cell envelope of the bacterium, this projects aims at characterizing the virulence potential of selected glycoproteins from the T. forsythia cell envelope. By understanding the molecular and cellular basis of the processes governing pathogenicity, it shall be possible to design rational approaches for controlling or even preventing periodontitis. T. forsythia glycan • Research goals • Expression and purification of the selected fucosyl-proteins from T. forsythia • Immunology studies with selected fucosyl-proteins(cooperation with the Department of Periodontology, General Hospital, Vienna) • Determination of the roles of selected fucosyl-proteins in biofilm formation T. forsythia Requirements The candidate must hold a MSc degree and should have a sound background in molecular biology, micro-biology, biochemistry. Practical experience in the fields of immunology and glycobiology is of advantage but not mandatory. The highly motivated candidate should be an excellent team player with the ability to work independently in an interdisciplinary environment. We offer Motivating scientific environment at the Vienna Institute of Biotechnology, cutting edge research in nanoglycobiology with a link to biomedical relevance, weekly seminars, participation in workshops andinternational conferences. Stays in partner laboratories abroad are possible. Funding opportunity according to the guidelines of FWF (http://www.fwf.ac.at/de/projects/einzelprojekte.html). Possibility of embedding the PhD thesis into the International PhD Programme BioToP (http://biotop.boku.ac.at/). Applicants Please e-mail your application with motivation, full CV and references along with contact addresses to: Ao.Univ.Prof. Dr. Christina Schäffer Dep. für NanoBiotechnologie, Universität für Bodenkultur Wien, Muthgasse 11, 1190 Wien e-mail: christina.schaeffer@boku.ac.at; Phone: 47654-2203

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