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Modeling and Simulation: Animal health experience

Modeling and Simulation: Animal health experience. PAGE 2013 Glasgow UK Jonathan Mochel, Novartis Advanced Quantitative Sciences. Workshop Animal Health Modeling & Simulation Society.

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Modeling and Simulation: Animal health experience

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  1. Modeling and Simulation: Animal health experience PAGE 2013 Glasgow UK Jonathan Mochel, Novartis Advanced Quantitative Sciences

  2. Workshop Animal Health Modeling & Simulation Society The Animal Health Modeling & Simulation Society (AHM&S) is a newly founded association (2012) that aims at promoting the development, application, and disseminationof modeling and simulation techniques in the field of Veterinary Pharmacology and Toxicology The association is co-chaired by Pr. Johan Gabrielsson (Europe) and Pr. Jim Riviere (USA), and currently consists of core members from both academia and industry Half-a-day workshop with presentation of modeling applications in the animal health field: • Methodological challenges with population PK in osteoarthritic dogs • Optimizing antimicrobial dosage regimens with mechanistic PK/PD modeling • Role of BSA and Hyperthermia on Carboplatin Dosing in Dogs • M&S: A Comprehensive Tool To Streamline Drug Development • Animal Health Regulatory Science Innovation Initiative (AHRSII) 2 | Peers Forum| J. Mochel | AHM&S PAGE 2013

  3. Main conference AH session: PAGE plenum • Food safety: intersection of pharmacometrics and veterinary medicine (Pr. J Riviere) • Presentation of physiological-based pharmacokinetics differences between species • Inherent sources of variability for collective therapy (e.g. dose most often unknown) • The application of population modeling to the calculation of residual levels and WT • Two models for the control of sea lice infections using chemical treatments and biological control on farmed salmon populations (Pr. G Gettinby) • Model-based approaches for capturing the infestation level of parasitized fishes • Population Model integrates biological stages of the parasite and drug effect (but not T°) • From epidemic to elimination: density-vague transmission and the design of mass dog vaccination programs (Pr. D Haydon) • High prevalence of rabbies in developing countries (Indonesia)-child death from dog bites • Simulation-based comparisons of vaccine strategies for eradicating rabbbies 3 | Peers Forum| J. Mochel | AHM&S PAGE 2013

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