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Bone Metabolism

Bone Metabolism. Rickets. Rickets (children) – failure of mineralization of the epiphyseal plate Related to lack of Vitamin D Dietary Poverty Third world countries Sunlight exposure Northern latitudes Sun screen Metabolic failure. Renal Osteodystrophy.

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Bone Metabolism

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  1. Bone Metabolism

  2. Rickets • Rickets (children) – failure of mineralization of the epiphyseal plate • Related to lack of Vitamin D • Dietary • Poverty • Third world countries • Sunlight exposure • Northern latitudes • Sun screen • Metabolic failure

  3. Renal Osteodystrophy • Osteomalacia (low bone density) – failure of mineralization of osteoid • Osteosclerosis (high bone density) – dense bones • Abnormal resorption of mineral • Abnormal deposition of mineral

  4. Renal Rickets • Child • Zone of provisional calcification is deficient • Metaphyses irregularly mineralized, widened and cupped • Fracture of distal fibula Images courtesy Nancy Fitzgerald, MD, Texas Children’s Hospital

  5. Rickets • Widening of the ribs at the costal-chondral junction • Known clinically as Rachitic Rosary

  6. Rickets Images courtesy Nancy Fitzgerald, MD, Texas Children’s Hospital

  7. Rickets • Widened metaphysis with fraying

  8. Rickets • Wrist film • Another patient • Cupping and fraying of metaphyses

  9. Treated Rickets • Same patient after 3 months of Vitamin D • Improved appearance with well defined slightly undulating metaphysis

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