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Research Focus: Searching for Novel Riboswitches in Newly Sequenced Genomes

Biological Application: RNAs. Research Focus: Searching for Novel Riboswitches in Newly Sequenced Genomes. Danny Barash † Department of Computer Science Ben-Gurion University † email: dbarash@cs.bgu.ac.il. With TPP. What are Riboswitches?. Terminator.

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Research Focus: Searching for Novel Riboswitches in Newly Sequenced Genomes

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  1. Biological Application: RNAs Research Focus: Searching for Novel Riboswitches in Newly Sequenced Genomes Danny Barash† Department of Computer Science Ben-Gurion University †email: dbarash@cs.bgu.ac.il Bioinformatics

  2. With TPP What are Riboswitches? Terminator Vitamin B1 biosynthesis in bacteria: TPP-mediated attentuation control: E. Nudler and coworkers: (Mironov et al., Cell, 2002) Thiamine pyrophosphate are the metabolites that alter conformation. Aptamer Bioinformatics

  3. Without TPP What are Riboswitches? Anti-terminator Vitamin B1 biosynthesis in bacteria: TPP-mediated attentuation control: E. Nudler and coworkers: (Mironov et al., Cell, 2002) Thiamine pyrophosphate are the metabolites that alter conformation. Aptamer Bioinformatics

  4. Searching for riboswitches ineukaryotes by their aptamer Sequence is not enough, need structure considerations! Bioinformatics

  5. Searching for riboswitches ineukaryotes by their aptamer (Cohen et al., In Silico Biology, 2008) – a riboswitch in plants? Our 3-stem junction candidate in plants Known consensus in bacteria Bioinformatics

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