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Biomedical applications of molecular imaging

Biomedical applications of molecular imaging. Tony Lahoutte UMons Nov-Dec 2011. Course 1. Part 1: Introduction and general principles. Biomedical Imaging. R önt gen. Hand of Anna Berthe 1895. Biomedical Imaging. R önt gen. 22 dec 1895 Hand of Anna Berthe. 23 January 1896

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Biomedical applications of molecular imaging

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  1. Biomedical applications of molecular imaging Tony Lahoutte UMons Nov-Dec 2011

  2. Course 1 Part 1: Introduction and general principles

  3. Biomedical Imaging Röntgen Hand of Anna Berthe 1895

  4. Biomedical Imaging Röntgen 22 dec 1895 Hand of Anna Berthe 23 January 1896 Hand of Albert von Kölliker

  5. Biomedical Imaging Weissleder and Pittet, Nature 2009

  6. Biomedical Imaging 1. Microscopy: In vitro samples or in vivo tissues 2. Preclinical Imaging: In vivo imaging in animal models 3. Clinical Imaging: Imaging in patients

  7. CT – X-ray MRI SPECT & PET Bioluminescence Fluorescence FRET/FRAP ImageStream Biomedical Imaging www.mi-central.org

  8. Biomedical Imaging Anatomy Physiology Cell Molecular Anatomical imaging: Organ and tissue morphology Physiologic Imaging: Organ and tissue function Molecular Imaging: Molecules and cells

  9. Molecular Imaging • Definition: • Molecular imaging is the visualization, the characterization and the measurement of biological processes at the molecular and cellular levels in living systems

  10. Hybrid Imaging Anatomical Molecular

  11. Anatomical CT scan of a women

  12. Molecular Glucose molecules

  13. PET-CT scan • Computed Tomography • or CT scan • Anatomical Positron Emission Tomography or PET scan • Molecular

  14. Anatomical + Molecular PET/CT fusion image

  15. Anatomical

  16. Molecular Radiolabeled antibody fragments that recognize cancer cells

  17. SPECT-CT

  18. Anatomical + Molecular SPECT/CT fusion image

  19. Anatomical MRI scan

  20. Anatomical + Molecular

  21. PET/MRI scanner Courtesy of University of Tübingen

  22. FMT/MRI FMT MRI Fluorescence Molecular Tomography/ Magnetic Resonance Imaging = FMT/MRI J. Chen, JCI, 2009: “Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy”

  23. FMT/CT FMT/CT fusion Nature 2008;452:580-589

  24. FMT scanner Imaging Near Infrared Fluorescence Visen

  25. Anatomical + Molecular PET/CT SPECT/CT PET/MRI FMT/MRI FMT/CT = Hybrid imaging

  26. Physiological Imaging • = Functional Imaging • visualizing cardiac contraction • Imaging blood perfusion • ...

  27. Planar and Tomographic Imaging Planar = 2D projection Tomographic = 3D volume

  28. Planar and Tomographic Imaging Gamma Camera

  29. Planar and Tomographic Imaging Anterior and posterior view of a planar bone scintigraphy Planar = 2D projection

  30. Planar and Tomographic Imaging Tomographic = 3D volume

  31. Static and Dynamic Imaging Static image= 1 time interval Dynamic image = multiple time intervals

  32. Static and Dynamic Imaging Static image of a radiolabeled antibody between 1-10 s after intravenous injection in a rat Static image = 1 time interval

  33. Static and Dynamic Imaging Dynamic image of a radiolabeled antibody between 1second and 10 min after intravenous injection in a rat. Every frame is 10 seconds Dynamic image = multiple time intervals

  34. Special case of dynamic: Gated Image Gated image = images are synchronized with cardiac contraction or respiration

  35. Special case of dynamic: Gated Image Gated image = images are synchronized with cardiac contraction or respiration

  36. Static and Dynamic Imaging Different combinations are possible: Static planar image Dynamic planar image Static tomographic image Dynamic tomographic image

  37. Slicing and orientation

  38. Slicing and orientation A Sagittal R L A L R Coronal Transverse

  39. Slicing and orientation R L Orientation: we look from the feet to the head

  40. Slicing and orientation R L Orientation: we look from the feet to the head

  41. Slicing and orientation R L Orientation: we look from the feet to the head

  42. Slicing and orientation R L Orientation: we look from the feet to the head

  43. Slicing and orientation R L Orientation: we look from the feet to the head

  44. Slicing and orientation R L Orientation: we look from the feet to the head

  45. Slicing and orientation R L Orientation: we look from the feet to the head

  46. End of part 1

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