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Publication. Cho, E., et al., Alcohol Intake and Colorectal Cancer: A Pooled Analysis of 8 Cohort Studies. Annals of Internal Medicine, 2004; 140: 603-613. Cohort Studies in the Pooled Analysis of Alcohol and Colorectal Cancer. Sweden Mammography Cohort.

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  1. Publication Cho, E., et al., Alcohol Intake and Colorectal Cancer: A Pooled Analysis of 8 Cohort Studies. Annals of Internal Medicine, 2004; 140: 603-613.

  2. Cohort Studies in the Pooled Analysis of Alcohol and Colorectal Cancer Sweden Mammography Cohort Canadian National Breast Screening Study Netherlands Cohort Study Nurses’ Health Study Health Professionals Follow-up Study New York State Cohort Alpha-Tocopherol Beta-Carotene Cancer Prevention Study Total = 489,979 # of cases = 4,687 Iowa Women’s Health Study Cho, et al., 2004

  3. Cohort Studies in the Pooled Analysis of Alcohol and Colorectal Cancer Study Total # of cohort cases ATBC 26,987 184 Canadian National Breast 56,837 284 Screening Study Health Professionals 47,673 408 Follow-up Study Iowa Women’s Health Study 34,603 796 Netherlands Cohort Study 120,852 1126 New York State Cohort 52,913 789 Nurses’ Health Study (a) 88,651 220 Nurses’ Health Study (b) 68,540 420 Sweden Mammography Cohort 61,463 460 Cho, et al., 2004

  4. Total Alcohol Intake Study % Drinkers Mean* (SD) (g/d) ATBC 89 20.3 (21.8) Canadian National 77 10.9 (14.5) Health Professionals 76 14.8 (16.1) Iowa Women’s 45 8.7 (12.3) Netherlands Study (W) 68 8.5 (10.6) Netherlands Study (M) 85 17.3 (16.7) New York State Cohort (W) 78 6.0 (9.4) New York State Cohort (M) 89 12.1 (17.1) Nurses’ Health Study (a) 68 9.4 (11.6) Nurses’ Health Study (b) 64 9.6 (12.1) Sweden Mammography Cohort 67 3.5 (3.5) *Among drinkers only Cho, et al., 2004

  5. Alcohol and Colorectal Cancer Intake No. of Multivariate RR (g/d) cases (95% CI) 0 1,466 1.00 (ref) >0-<5 1,475 0.94 (0.86-1.03) 5-<15 849 0.97 (0.88-1.06) 15-<30 485 1.01 (0.86-1.18) 30-<45 244 1.16 (0.99-1.36) >45 168 1.41 (1.16-1.72) P for trend <0.001 Cho, et al., 2004

  6. Study-Specific Relative Risks for Colorectal Cancer for Alcohol Intake > 30 vs. 0g/d Cho, et al., 2004

  7. Alcohol Intake and Colorectal Cancer by Tumor Site RR (95% CI) Intake (g/d) Colon Rectum 0 1.00 1.00 >0 - <5 0.92 1.01 5 - <15 0.94 0.99 15 - <30 1.01 1.05 30 - <45 1.08 1.42 >45 1.45 1.49 (1.14-1.83) (1.04-2.12) P for trend <0.001 0.006 Cho, et al., 2004

  8. Alcoholic Beverages and Colorectal Cancer Intake Beer Wine Liquor (g/d) 0 1.00 1.00 1.00 >0-<30 1.01 0.97 0.98 >30 1.37 1.82 1.21 (1.00-1.87) (1.28-2.59) (0.99-1.47) P for trend 0.2 0.001 0.1 Cho, et al., 2004

  9. Alcoholic Beverages and Colorectal Cancer by Tumor Site Alcoholic Tumor RR (95% CI) beverage site (>15 vs. 0 g/d) Beer Colon 1.38 (1.05-1.82) Rectum 1.59 (1.12-2.25) Wine Colon 1.33 (1.00-1.77) Rectum 1.55 (1.11-2.17) Liquor Colon 1.06 (0.86-1.30) Rectum 1.10 (0.85-1.41) For each beverage, the differences by tumor site were not statistically significant. Cho, et al., 2004

  10. Alcohol and Colorectal Cancer by Body Mass Index * Relative Risk P for interaction=0.03 0 >0- <5 5-<15 15-<30 >30 *P<0.05 Alcohol (g/d) BMI <22 22-<25 25+ kg/m2 Cho, et al., 2004

  11. Alcohol and Colorectal Cancer by Multivitamin Use * Relative Risk P for interaction >0.2 0 >0-<5 5-<15 15-<30 >30 Alcohol (g/d) *P<0.05 Users Nonusers Cho, et al., 2004

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