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免疫学基础 Basic immunology

免疫学基础 Basic immunology. 2012 级本科讲义. 免疫学的诞生 The birth of immunology. 被 主赐予恩宠者，将 免于疾病 之苦 Im-munitas 免税、免役 Immunity 免疫. 席卷欧洲的“黑死病” The Black Death that swept through Europe.

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免疫学基础 Basic immunology

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  1. 免疫学基础Basic immunology 2012级本科讲义

  2. 免疫学的诞生The birth of immunology 被主赐予恩宠者，将免于疾病之苦 Im-munitas 免税、免役 Immunity 免疫

  3. 席卷欧洲的“黑死病” The Black Death that swept through Europe 受害者发病那一天，水泡和疖子出现在胳膊、大腿和脖子上。他们非常虚弱，备受折磨，只能倚靠在床上。不久，疖子变成核桃那么大，然后变成鸡蛋或鹅蛋大小，那种感觉痛彻心肺。病症会持续三天，到了第四天，又一个孤魂升入了天国

  4. 当瘟疫爆发时，不管是富人还是穷人，男人还是女人，在疾病面前一律平等当瘟疫爆发时，不管是富人还是穷人，男人还是女人，在疾病面前一律平等

  5. “主要治疗方案”Primary prevention programs 为什么致死率超过30%的瘟疫在欧洲横行了四个世纪之久

  6. 瘟疫不会致命地侵袭同一个人两次Fortunately, infection of the plague provided immunity; that is, few caught the disease twice, and if this occurred, the second attack was never fatal.——Thucydides 【古希腊】修昔底德 公元前410年 【法】路易·巴斯德 The method for attenuatio of virulent microorganisms 公元1885年

  7. 首次疫苗预防狂犬病和炭疽病The first vaccines for rabies and anthrax

  8. 爱德华·詹纳的人体实验Edward Jenner's human subject research Vaccine 疫苗 Vacca母牛

  9. 实验危险切勿模仿Don't try to imitate, That is very dangerous 10,000英镑

  10. 小组发表指定课题一览List of group presentation topics

  11. 先天免疫系统Innate immunity system • 物理屏障 • 中性粒细胞 • 巨噬细胞 • 自然杀伤细胞 • 补体 • 细胞因子 • ...... 古老、快速、广谱

  12. 获得性免疫系统Acquired immunity system • B细胞、抗体 • T细胞、抗原提呈 • 记忆T细胞…… 多样、高效、记忆

  13. 抗体多样性的产生The generation of antibody diversity “Both somatic recombination and mutation contribute greatly to an increase in the diversity of antibody synthesized by a single organism” Susumu Tonegawa Nature 302, 575 - 581 (1983)

  14. 抗原的提呈Antigen presentation Zinkernagel Doherty 1996 NOBEL PRIZE

  15. 免疫记忆与免疫耐受Immunological memory and immunological tolerance

  16. 免疫器官Organs of the immune system

  17. 重新认识“自我”Rediscover "myself"

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