1 / 22

Hibernation, Aging and Longevity

Hibernation, Aging and Longevity. Natalia S. Gavrilova Leonid A. Gavrilov Center on Aging, NORC/University of Chicago, 1155 East 60th Street, Chicago, IL 60637. Study of Turkish hamsters, Science, 1981. Hibernation and longevity. a) Longevity of all hamsters in the study.

karan
Télécharger la présentation

Hibernation, Aging and Longevity

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Hibernation, Aging and Longevity Natalia S. Gavrilova Leonid A. Gavrilov Center on Aging, NORC/University of Chicago, 1155 East 60th Street, Chicago, IL 60637

  2. Study of Turkish hamsters, Science, 1981

  3. Hibernation and longevity a) Longevity of all hamsters in the study. b) Longevity of the poor, moderate and good hibernators in the study

  4. Hibernation correlates with longevity r=0.522 p<0.001

  5. Distribution of deaths in (a) control and (b) experimental hamsters • Number of deaths against age at death at intervals of 60 days for a) control hamsters (mean = 812 days, median = 843 days) b) experimental hamsters (mean = 914 days, median = 884 days)

  6. Hibernation and Longevity in Bats

  7. Hibernation and Longevity in Bat Species (a) Average longevity for bat species that do and do not hibernate. • Numbers indicate sample size in each category. (b) Average change in longevity between phylogenically independent comparisons in which hibernation was acquired.

  8. Predictors of longevity in bats based on ANCOVA for species and bivariate analysis of contrasts

  9. Hibernation is not continuous! There are cycles of hibernation and short awakening (every week in ground squirrels)

  10. You don't need to hibernate in order to delay aging: Hibernation signals (darkness) may be sufficient!

  11. Study of Siberian Hamster

  12. Day length and reproductive success in females of Siberian hamsters A) Reproductive success of long-day (LD), short-day (SD) and short-day pinealectomized (SD-PX) females expressed as the percentage of females mated at 9 mo of age that delivered live litters. B) Mean + SEM live litter size at birth and weaning.

  13. Short-day exposure and delaying reproductive senescence in females of Siberian hamster • Mean + SEM number of primordial follicles per ovary in SD and LD females at 13 and 26 wk of age. Asterisk (*) denotes significant effect of photoperiodic treatment at both ages

  14. Growth curves for hamsters subjected to LD and SD exposure • Mean + SEM body mass (grams) of LD, SD, and SD-PX females from weaning at Postnatal Day 18 to 40 wk of age.

  15. Conclusion: Лампочка Ильича ускоряет старение!

  16. Study of Black Bears

  17. Black bear: active and hibernating

  18. Hibernating Bears are Hot! • Body temperature: 30 - 34 C Reference: Carey HV, Andrews MT, Martin SL.  Mammalian hibernation: cellular and molecular responses to depressed metabolism and low temperature. Physiol Rev. 2003 Oct;83(4):1153-81. Review. PMID: 14506303

  19. Hibernating bears do not experience osteoporosis

  20. What About Humans?

  21. For More Information and Updates Visit Our Website: http://longevity-science.org You are Welcome to Post Your Comments at our Blog: http://longevity-science.blogspot.com/

More Related