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Autologous Stem Cells with Allograft Equivalent to Autograft for Spinal Fusions

Autologous Stem Cells with Allograft Equivalent to Autograft for Spinal Fusions. A Prospective, Randomized Pilot Study. Robert Johnson, MD, Sherwin Kevy , MD, May Jacobson, PhD. Autograft - Why Change?.

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Autologous Stem Cells with Allograft Equivalent to Autograft for Spinal Fusions

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  1. Autologous Stem Cells with Allograft Equivalent to Autograft for Spinal Fusions A Prospective, Randomized Pilot Study Robert Johnson, MD, Sherwin Kevy, MD, May Jacobson, PhD

  2. Autograft- Why Change?

  3. A Prospective, Randomized Pilot Study of Point of Care, Concentrate, Autologous Stem Cells vs. Autologous Iliac Crest Bone for Instrumented Fusion of the Lumbar Spine • 25 patient prospective blinded study (ages 18 to 65 yrs of age) • IRB approved • 1-3 level posterior lumbar fusions • CT Scan at 1 yr follow up

  4. Bone Marrow Aspiration

  5. X-Rays Stem Cell Matrix ICBG ICBG A Prospective, Randomized Study of Point of Care, Concentrate, Autologous Stem Cells vs. Autologous Iliac Crest Bone For Instrumented Fusion of the Lumbar Spine

  6. 1 Year CT Stem Cells ICBG A Prospective, Randomized Study of Point of Care, Concentrate, Autologous Stem Cells vs. Autologous Iliac Crest Bone For Instrumented Fusion of the Lumbar Spine

  7. Radiographic Scale A Prospective, Randomized Study of Point of Care, Concentrate, Autologous Stem Cells vs. Autologous Iliac Crest Bone For Instrumented Fusion of the Lumbar Spine 0 = No Fusion 1 = Undetermined fusion 2 = Fusion

  8. Stem Cells ICBG A Prospective, Randomized Study of Point of Care, Concentrate, Autologous Stem Cells vs. Autologous Iliac Crest Bone For Instrumented Fusion of the Lumbar Spine

  9. Scale of Fusion = 2 Scale of Fusion = 0 A Prospective, Randomized Study of Point of Care, Concentrate, Autologous Stem Cells vs. Autologous Iliac Crest Bone For Instrumented Fusion of the Lumbar Spine

  10. 1 Year CT Stem Cells Scale of Fusion = 2 A Prospective, Randomized Study of Point of Care, Concentrate, Autologous Stem Cells vs. Autologous Iliac Crest Bone For Instrumented Fusion of the Lumbar Spine

  11. Scale of Fusion = 0 A Prospective, Randomized Study of Point of Care, Concentrate, Autologous Stem Cells vs. Autologous Iliac Crest Bone For Instrumented Fusion of the Lumbar Spine

  12. Scale of Fusion = 0 Scale of Fusion = 1 A Prospective, Randomized Study of Point of Care, Concentrate, Autologous Stem Cells vs. Autologous Iliac Crest Bone For Instrumented Fusion of the Lumbar Spine

  13. 1 Year CT Stem Cells ICBG A Prospective, Randomized Study of Point of Care, Concentrate, Autologous Stem Cells vs. Autologous Iliac Crest Bone For Instrumented Fusion of the Lumbar Spine

  14. Concentration of Cells A Prospective, Randomized Study of Point of Care, Concentrate, Autologous Stem Cells vs. Autologous Iliac Crest Bone For Instrumented Fusion of the Lumbar Spine

  15. Fusion Rates p Value * = .484 * p Value for difference in treatments, all levels combined Mann-Whitney rank sum test

  16. Bone Graft & Bone Graft Substitutes AAOS “In contrast to results using interbody structural allografts placed under compression, results using posterior non-structural allografts placed under tension are less positive. Allograft is considered a poor alternative to autograft in this situation and usually is considered only as a bone graft supplement.”

  17. Growing Bone conductive Osteo inductive genesis

  18. Summary: Autologus Adult, Stem Cell Concentrate • Bone marrow can easily & quickly be harvested from the iliac crest • Adult Stem Cells can be separated from bone marrow & concentrated by a simple device in the OR • Concentrated Adult Stem Cells combined with scaffold • Reduces the need for autograft • Reduces donor site morbidity • Provides a renewable source of osteogenic stem cell • Lowers cost alternative to BMP

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