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Tau Dataset Analysis

Tau Dataset Analysis. PHF tau phosphorylation and ubiquitination sites (isoform 2). P. MAEPR QEFEV MEDHAGTYGL GDR K DQGGYT MHQDQEGDTD AGLKESPLQT PTEDGSEEPG SETSDAKSTP TAEDVTAPLV DEGAPGK QAA AQPHTEIPEG TT AEEAGIGD TPSLEDEAAG HVTQAR MVSK SKDGTGSDDK KAKGADGKTK

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Tau Dataset Analysis

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  1. Tau Dataset Analysis

  2. PHF tau phosphorylation and ubiquitination sites (isoform 2) P MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQT PTEDGSEEPG SETSDAKSTPTAEDVTAPLVDEGAPGKQAA AQPHTEIPEG TTAEEAGIGDTPSLEDEAAGHVTQARMVSK SKDGTGSDDK KAKGADGKTK IATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPK SGDRSGYSSP GSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPM PDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSK CGSKDNIKHV PGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE NAKAKTDHGA EIVYKSPVVS GDTSPRHLSN VSSTGSIDMVDSPQLATLADEVSASLAKQG L P P U U P P P P P P P P P P U P P U P U U U U P U P P U U P P P P P BLUE = sequence coverage; = phosphorylation; = ubiquitination P U

  3. Ubiquitin Sequence 6 11 MQIFVKTLTG KTITLEVEPS DTIENVKAKI 18 QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN 63 IQKESTLHLV LRLRGG

  4. K6: MQIFK@TLTGK K11: TLTGK@TITLEVEPSDTIENVK K48: LIFAGK@QLEDGR K63: TLSDYNIQK@ESTLHLVLR For LysC digestion, we didn’t identify any ubiquitation sites since LysC doesn’t cut on R.

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