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Functional hydrogel structures for autonomous flow control inside microfluidic channels

Functional hydrogel structures for autonomous flow control inside microfluidic channels. D. J. Beebe, J. S. Moore, J. M. Bauer, Q. Yu, R. H. Liu, C. Devadoss & B-H Jo Presented by Gabriel Man EECE 491C. What are hydrogels?. Sounds like a weird “glue” or “blob” type of material

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Functional hydrogel structures for autonomous flow control inside microfluidic channels

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  1. Functional hydrogel structures for autonomous flow control inside microfluidic channels D. J. Beebe, J. S. Moore, J. M. Bauer, Q. Yu, R. H. Liu, C. Devadoss & B-H Jo Presented by Gabriel Man EECE 491C

  2. What are hydrogels? • Sounds like a weird “glue” or “blob” type of material • Network of super-absorbent, natural or synthetic polymer chains EECE 491C

  3. Research Goals • Eliminate sensors and/or actuators requiring external power: self-regulated flow control • Simplify system construction and assembly by fabricating hydrogels in situ EECE 491C

  4. Applications • Combined sensor and actuator (sense chemical environment in one channel, regulate flow in adjacent channel) – pH-sensitive throttle valve • Self-regulated drug delivery or biosensors featuring antigen-responsive hydrogels EECE 491C

  5. Fabrication Techniques Combines: • Lithography • Photopolymerization • Microfluidics • Flow a mixture of monomers and a photoinitiator into microchannel • Place the photomask over the channel, expose to UV light EECE 491C

  6. Fabrication Techniques Con’t • Polymerization times can be < 20 seconds • Flush the channel with water to remove unpolymerized liquid 250 μm EECE 491C Yeast (Saccharomyces cerevisiae) surrounded by E.Coli (1-2 μm in length)

  7. Results: Flow Sorter • Hydrogel objects reversibly expand and contract depending on pH of environment Inflow Outflow Outflow Time Response 1.0 0.0 200 400 600 800 1000 1200 Time (seconds) EECE 491C 300 μm

  8. Results: Throttle Valve • Pressure drop of 0.09 PSI to 0.72 PSI in top channel • Force associated with volumetric changes sufficient to deform membrane and control flow in lower channel EECE 491C

  9. Results: Another Flow Sorter 1.0 0.8 0.6 0.4 0.2 1 3 5 7 9 11 13 pH EECE 491C

  10. Conclusions • Approach can be “extended to build multifunctional microfluidic systems, allowing complex fluidic processes to be performed autonomously” • Eliminates microscale assembly and external electronics for sensing/actuation • Scaling down hydrogel structures to the micro-scale improves response time EECE 491C

  11. Critique Summary EECE 491C

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