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RESULTS Stage I-II

Incidence of lung cancer in Europe cases/100.000 males. cumulative survival. cumulative survival. Role of (18)FDG-PET/CT and SUV evaluation in the management of Non-Small Cell Lung Cancer in different stages. A. Cistaro 1 , N. Q uartuccio 2 , M.A. Rimicci 2 , P. Fania 1 , U. Ficola 2.

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RESULTS Stage I-II

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  1. Incidence of lung cancer in Europe cases/100.000 males cumulative survival cumulative survival Role of (18)FDG-PET/CT and SUV evaluation in the management of Non-Small Cell Lung Cancer in different stages A. Cistaro1,N.Quartuccio2, M.A. Rimicci2, P. Fania1, U. Ficola2 1 Positron Emission Tomography Center IRMET S.p.A., Turin, Italy 2 Nuclear Medicine Dept. “La Maddalena” Hospital, Palermo, Italy • PURPOSES • To evaluate the correlation between SUVmax and clinical outcome in two different groups of patients: • patients with NSCLC in stage I-II undergoing surgery; • patients with NSCLC in stage III-IV undergoing chemotherapy MATHERIALS AND METODS - 135 patients (49 stage I-II, 86 stage III-IV), underwent 2 (18)FDG-PET whole body. - SUVmax and dimension of the lesion were recorded. - In the group of patients in stage I-II SUVmax and clinical outcome were put in relationship by Student-t test, and the optimal cut-off value of SUVmax to predict prognosis was calculated. The probability of Disease-Free Survival was investigated through the univariate analysis of Kaplan-Meier. - In the group of stage III-IV patients we looked for a possible correlation between SUVmax and best response, and for the most significant cut-off value of SUVmax to predict prognosis. RESULTS Stage I-II Mean SUVmax: 8,96 Diam medium: 32,27 mm A: Disease-free: 35 pts 49 pts SUVmax medium:10 Diam med: 33mm Mean SUVmax: 12,8 Diam medium: 40,5 mm B: Disease relapse:13pts RESULTS Stage III-IV Population of patients in stage III-IV presented a mean SUVmax of 12,5 and the average diameter of the primitive lesions was42 m. The patients, were classified in : - 22 PD(progressive disease), - 33 PR(partial response), - 24 SD(stable disease), - 7 RC (complete response). Patients were then divided in two groups according to the follow-up: - Group P: patients with progressive disease (PD): 22, average SUVmax11,8(SD: 5,23), medium diameter of primitive lesion 43,35 mm (SD: 16,63). - Group C: patient with disease under control [(PR), (SD), (RC)]: 64, average SUVmax value12,7 (SD: 8,05) and medium diameter of primitive lesion 41,6 mm (SD: 21,15). CONCLUSIONS Stage I-II patients with SUVmax>9 (cut-off value)and diameter of lesion>30mm (cut-off value) reported the worst prognosis. An important correlation exists between responses according to CT and FDG-PET. In stages III and IV, no reliable cut-off value of SUVmax was found in correlation with prognosis and response to therapy.

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