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Responding To External Challenges and Opportunities:

Responding To External Challenges and Opportunities:. Research at UPR at The Beginning of Its Second Century. Presented at NSF Caribbean Colloquium on Power Quality (CCPQ) 2003 Dr. Manuel Gómez Vice President for Research and Technology Dorado, PR June 25, 2003. m_gomez@upr.edu

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Responding To External Challenges and Opportunities:

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  1. Responding To External Challenges and Opportunities: Research at UPR at The Beginning of Its Second Century Presented at NSF Caribbean Colloquium on Power Quality (CCPQ) 2003 Dr. Manuel Gómez Vice President for Research and Technology Dorado, PR June 25, 2003 m_gomez@upr.edu UPR: http://www.upr.clu.edu ; Central Administration: http://acosi.upr.clu.edu EPSCoR: http://web.uprr.pr ; PR-LSAMP: http://shuttle.uprm.edu/prlsamp/bpc; Scientific Community: http://web.uprr.pr/wais

  2. An Issue of Scale Puerto Rico at a Glance Location of the UPRGraduate Campuses Geography and Demographics Area: 3,434 square miles (» Rhode Island’s) Population: 3.8 M (>25 states) The Economy K-12 Ed. System Higher Education System GDP: $48B Exports: $23.9B Manufacturing: 41% of GDP S&T Industries: Pharmaceuticals Electronics Medical Devises Service: 48% of GDP Total Enrollment: 800,000 Public Enrollment: 620,000 (»L.A. Unified School Dist.) Public Schools: 1,540 Enrollment in Higher Education: 170,000 (the sixth highest rate of enrollment in the world) UPR System: 70,000 (41% of Higher Education Enrollment) SMET Degrees Conferred UPR: 2,000 (71%); Private Institution: 800 (29%) UPR School of Engineering: 9th largest in the nation 2

  3. The University of Puerto Ricoas it Enters its Second Century 3

  4. UPR System at a Glance • UPR was founded in 1983 and since its inception has conferred more than 300,000 degrees: UPR has educated most of the top leadership of the Island. • UPR is the premier Hispanic serving institution in the United States, with an enrollment of 70,000 students. • UPR is a multicampus system with 11 campuses: eight 4-year institutions and three graduate campuses. The graduate campuses are: UPR-Mayagüez, UPR-Río Piedras, and UPR-Medical Sciences. • UPR conferred 10,020 academic degrees in year 2002. • UPR graduate programs are developing very quickly: it conferred 100 PhD’s last year. • UPR offers 499 different degrees including 22 PhD programs. • UPR’s three graduate campuses aspire to become Research I Institutions, according to the Carnegie Classification. UPR-Río Piedras is already a Doctoral Research Intensive Institution, according to the Carnegie Classification. • UPR’s research activity, as measured by external funding, has grown exponentially since 1985, doubling every five years. For year 2001-2002, it received $62M in external funding for research. • UPR is member of INTERNET2; has teleconferencing facilities in every campus; its three graduate campuses are connected by OC-3 lines and a GigaPoP connects then to the mainland through an OC-3 line. 4

  5. The Traditional University Higher Education and the Rest of the Educational Continuum Undergraduate Pre-College Graduate Human Resources Human Resources knowledge knowledge K - 12 13 - 16 16+ and PhD's reform reform reform Human Resources; knowledge Technology Transfer; Intellectual Property; Human Resources Human Resources Economic Development 5

  6. The Engaged University The Seamless Continuum: Strongly Coupled S&T Reform Process Between Higher Education and the Rest of the Educational Continuum Undergraduate Pre-College Graduate Human Resources Human Resources knowledge knowledge K - 12 13 - 16 16+ and PhD's knowledge; knowledge; well prepared quality faculty reform reform reform teachers knowledge, strategic knowledge alliances; Human catalytic resources Resources; knowledge catalytic resources knowledge catalytic resources Technology Transfer; Intellectual Property; Human Resources Human Resources Economic Development S&T Policy for State or Region 6

  7. The University of Puerto RicoEducates the Next Generation of the Science and Technology Workforce 7

  8. 17,500 2,400 16,500 2,200 Enrollment Degrees 15,500 2,000 14,500 1,800 13,500 1,600 12,500 1,400 Degrees confered per year 11,500 Total enrollment 1,200 10,500 9,500 1,000 85-86 86-87 87-88 88-89 89-90 90-91 91-92 92-93 93-94 94-95 95-96 96-97 97-98 98-99 99-00 00-01 90-91 91-92 92-93 93-94 94-95 95-96 96-97 97-98 98-99 99-00 00-01 Enrollment Degrees Total Enrollment in Science & Technology and Bachelors in Science Degrees Conferred Per Year for the University of Puerto Rico Year 8

  9. Date of Creation and Number of Degrees Conferred in the Natural Sciences and Engineering by Doctoral Program at UPR 9

  10. Date of Creation and Number of Degrees Conferred in the Natural Sciences and Engineering by Doctoral Program at UPR (Cont.) 10

  11. 49 31 25 22 17 17 16 14 12 9 10 9 PhDs Conferred in Natural Sciences, Medical Sciences, and Engineering at UPR 50 45 40 35 30 # Ph’sD Conferred 25 20 15 10 5 0 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 Academic Year 11

  12. The University of Puerto RicoBecomes the First Research I University in Puerto Rico by Strengthening PhD Programs and Fostering Competitive Research in its Three Graduate Campuses 12

  13. Developing Three Research I Campuses At the University of Puerto Rico System Present Level Carnegie Carnegie Projected Level of Activity Classification Classification of Activity 2000 2005 (2005) PhD 12 16 PhD in five years programs programs 1) Río Piedras Doctoral/Research Doctoral/Research 60 90 PhD's PhD's Campus University, Intensive University, Extensive per Year per Year $12M $30M in in R&D Funds R&D Funds in five years 5 5 PhD PhD Specialized Specialized programs programs Institution Institution 2) Medical [All Independent [All Independent PhD's 10 20 Sciences PhD's Medical Sciences Medical Sciences per Year per Year Campus Campuses and Campuses and $19M $40M Medical Schools] Medical Schools] in in R&D Funds R&D Funds in five years 4 7 PhD PhD programs programs Masters Doctoral/Research 3) Mayagüez (Comprehensive) University, Intensive 6 15 Campus College or University PhD's PhD's per Year per Year $13M $35M in in 13 R&D Funds R&D Funds

  14. 100 90 80 Public 70 Private 60 Expenditures ($ in Millions) 50 40 30 20 10 0 1972 1973 1974 1975 1976 1977 1978 1979 1980 1981 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 Year R&D Expenditures in Puerto Rico Universities (NSF DATA) 14

  15. $ 56.65 M $ 23.46 M Growth in UPR External Funds for R+D 1992-93 to 2001-02 $60 $55 $50 $45 External Fund for R&D (in millions) $40 $35 $30 $25 $20 92-93 93-94 94-95 95-96 96-97 97-98 98-99 99-00 00-01 01-02 Academic Year Net Growth in a 10 Year Period Resulted in 2.4 increase in available funds. 15

  16. Publications in Peer Reviewed Science and Technology* Journals of the University of Puerto Rico (Information from the Science Citation Index**) 950 *** 1000 900 800 700 510 600 500 313 400 # of Peer Reviewed Publications 228 300 154 200 100 0 85-86 92-93 98-99 04-05 2001-02 Year # of researchers At UPR 280 340 365 600 Publications per Researcher (0.6) (0.7) (0.9) (1.5) * Science and Technology: Includes Natural Sciences, Mathematics, Medicine, Agriculture and Engineering ** Source: "Science Citation Index" *** The curve represents a 10% compounded growth rate 16

  17. 17

  18. R&D IN SCIENCE & TECHNOLOGY FIELDS IS A TOP PRIORITY FOR UPR IN ORDER TO PROVIDE THE INFRASTRUCTURE FOR AN S&T DRIVEN ECONOMY FOR PUERTO RICO • The Government approved an S&T Policy in October, 1996. A strategic plan is being developed for its implementation. • The UPR Board of Trustees approved an S&T Policy in 1997 to channel resources and give priority to increase the number and quality of PhDs, intensify R&D activity, and promote the protection and commercialization of intellectual property in support of the Government's S&T Policy. • Since 1985 with funds from NSF, DOE, DOD, NASA, and EPA, the Experimental Program to Stimulate Competitive Research (EPSCoR) has accelerate the development of infrastructure and nurture competitive R&D in Puerto Rico. With an annual budget in excess of $12M, more than 150 researchers carry on cutting edge research in five thrust areas. 18

  19. NSF EPSCoR NASA EPSCoR DEPSCoR DoE EPSCoR Development of target areas based on existing capabilities, growth potential, and contribution to the Island’s economy PR-EPSCoR Thrust Areas Evolution NIH IDEA NSF EPSCoR Phase IV NSF EPSCoR Phase V Integrative Biomolecular Processes Biotechnology Engineering Infrastructure Environmental Research Environmental Science and Engineering Information Technology Research High Performance Computing Materials Science Materials Science External Peer Assessment American Association for the Advancement of Science NSF EPSCoR Phase V Funds: $13.5M 19

  20. Engineering Research Centers Initiative 20

  21. A STRATEGY TO DEVELOP STATE-OF-THE ARTENGINEERING RESEARCH CENTERS • UPR is actively participating in three ERC’s • Center for Subsurface Sensing and Imaging Systems (CenSSIS) • An alliance with Rensselaer Polytechnic Institute, Northeastern University, and Boston University • Partnership with research hospital and marine stations • Research in remote sensing of biological systems, submarine exploration and subsoil sensing • Development of test-beds to develop new remote sensing technologies • Partnership with industries 21

  22. A STRATEGY TO DEVELOP STATE-OF-THE ARTENGINEERING RESEARCH CENTERS (Cont.) • Center for Collaborative Adaptive Sensing of the Atmosphere (CASA) • Collaboration with University of Massachusetts, University of Oklahoma, and Colorado State University • Industrial partners: Hewlett Packard and Verizon • Radar network for detection of every day and extreme meteorological events • Integration of information on extreme meteorological events with the needs of emergency management agencies and the public 22

  23. CENTER FOR POWER ELECTRONICS SYSTEMS

  24. Electric Energy Processing System Laboratory (E2PSyL) • Three main areas: • component testing and prototyping • component modeling and simulation • power quality and energy conversion • Multi-disciplinary projects • Industrial and Mechanical Engineering (CPES) • NSF and UPRM funds (over $350k) • Dr. Vélez-Reyes PECASE award 1997 • Dr. Efraín O’Neill NSF MRI Award 2001 24

  25. Acquisition of Instrumentation for the Electric Energy Processing Systems Laboratory at UPRM NSF Major Research Instrumentation Grant (MRI) Dr. Efraín O’Neill-Carrillo, PI Dr. Miguel Vélez-Reyes, Co-PI Dr. Lionel Orama-Exclusa, Co-PI Dr. Agustín Irizarry-Rivera, Co-PI Dr. José R. Cedeño-Maldonado, Co-PI 25

  26. Research Infrastructure • Enhancement of research capabilities at E2PSyL • Power electronics • Electric drives • Power quality • Transient studies • Improved computational capabilities 26

  27. Biotechnology Initiative 27

  28. Federal EPSCoR Funding (1990-2003) 450 400 350 300 NSF 250 DOE $$ (in millions) USDA 200 NIH DoD 150 NASA 100 EPA DOC 50 Total 0 FY90 FY91 FY92 FY93 FY94 FY95 FY96 FY97 FY98 FY99 FY00 FY01 FY02 FY03 Fiscal Year projected 28

  29. The University of Puerto RicoImplements a Multicampus a Strategy to Develop its R&D Capacity in Biotechnology using NIH Funds 29

  30. Biotechnological and Pharmaceutical Industries The Biotechnology Trilogy 2001 COBRE I Center for Molecular, Developmental and Behavioral Science COBRE II BRIN Center for Research in Protein Structure, Function and Dynamics Biomedical Research; Bioinformatics Infrastructure Network NIH Funds: $24.5M UPR Matched Funds: $6.5M 30

  31. University of Puerto Rico Center for Molecular, Developmental and Behavioral Neuroscience COBRE I 31

  32. University of Puerto Rico COBRE Center for Molecular, Developmental and Behavioral Neuroscience • Projects: • Molecular mechanism of brain injury: P2Y2 nucleotide receptor in ischemia. Fernando A. González, Ph.D. • Emotional memory: Genomic basis of emotional learning and memory. Sandra Peña, Ph.D. • Cocaine-seeking behavior: Neural and molecular mechanisms in striatal learning. Carmen Maldonado, Ph.D. • Development of maternal behavior: Neurosteroid effects on the structure and function of a sexually dimorphic mammalian brain network. Juan C. Jorge, Ph.D. 32

  33. NIH-COBRE II Program UPR- Protein Research Center 33

  34. UPR- Protein Research Center Center for Research in Protein Structure, Function and Dynamics Sponsored by the National Institutes of Health-Centers of Biomedical Research Excellence (NIH-COBRE II) Program NIH Funding Period: Oct. 2001- Sept 2006 ($8 Million / 5 years) 34

  35. CURRENT PROJECTS & PI’s • Protein Structure, Dynamics, and Function. Dr. Juan López Garriga - Chemistry UPR-Mayagüez Dr. Carmen Cadilla– Biochemistry-UPR-Medical Sciences • Aimed at understanding the reactions between hemoglobin (Hb), myoglobin (Mb), and other heme proteins with H2O2. • Protein Interactions and Oligomerization. Dr. Belinda Pastrana - Ríos - Chemistry UPR-Mayagüez Dr. Elsa M. Cora – Biochemistry-UPR-Medical Sciences • Aimed at studying serum 110 kD-sEGFR, a circulating serum biomarker for epithelial ovarian cancer (EOC), a protein generated by alternative splicing of the EGFR message. • Protein Stability and Delivery. Dr. Kai Griebenow - Chemistry- UPR-Río Piedras. Dr. Reinhard Schweitzer-Stenner - Chemistry- UPR-Río Piedras. • Aimed at studies on the improvement of the controlled delivery of proteins from biocompatible poly(lactide-co-glycolide) (PLG) by increasing their lifetime 35

  36. Biomedical Research Infrastructure Networks in Puerto Rico (BRIN-PR) Dr. Fernando A. González, P.I. Institutional Development Award (IDeA) 36

  37. BRIN Purpose • …to establish Biomedical Research Infrastructure Networks (BRIN) to further enhance the research capacity of institutions through collaborative partnerships. 37

  38. BRIN Organization 38

  39. COBRE I Center for Molecular, Developmental and Behavioral Neuroscience COBRE II Center for Research in Protein Structure, Function and Dynamics COBRE III Center for Clinical Proteomics (Submitted) BRIN Bioinformatics HPCf COBRE IV Microarray Analysis (Planned) Using NIH Funds to Expand UPR Biotechnology R+D Initiative by Creating New Research Programs Approved Funds $30.5M Expected New NIH Funds $20M 39

  40. COBRE IVCenter for Bioinformatics • Brings Mathematicians, Statisticians, Bioinformaticians, Biologist and Chemical Engineer in a Multidisciplinary/Multicampus Team to study and model microarrays. • Will develop the following microarray areas: • Simulation and reverse engineering problem of genetic networks. • Gene network design and error correction for microarrays • Microarray expression analysis: statistical significance of expression changes • Microarray data analysis • Will also develop the following Bioinformatic thrusts: • Pattern recognition in tandem mass spectrometry. • Statistical significance of multiple sequences alignment and gapped local alignments. • Proposed Five Year Budget: $10M(NIH + UPR) 40

  41. Academic/Industry Partnershipfor Innovation 41

  42. The NSF Partnerships for Innovation (PFI) Puerto Rico received a PFI to accelerate the Innovation Process (February, 2001): Mission of the PFI DevelopIdeation to Commercialization pathways to achieve innovation The PFI is an Alliance of: Academia: University of Puerto Rico Polytechnic University Inter American University Business: P.R. Chamber of Commerce P.R. Manufacturer’s Association Advent Morro Equity Partners (Venture Capital) MOVA Pharmaceutical INDUNIV Virtual, Inc. (Commercial Incubator) Government: Federal Small Business Administration P.R. Department of Economic Development and Commerce 42

  43. Goals and Objectives of PFI Goal Create a continuous pipeline for innovation: fromideation to commercialization.  Objectives A. Develop Entrepreneurial skills and nurture an innovation competent workforce. • Incorporate curricular materials on the nature of technology and innovation in the K-12 curriculum. • Entrepreneurship development program for undergraduates. • Develop new Ph.D.’s of relevance to innovation • Materials Science • Computational Sciences & Engineering • Medical Biotechnology 43

  44. Goals and Objectives of PFI (cont.) • Improve Access to New Knowledge to Drive the Innovation Process • PFI – Web-based Interactive S&T Resources Data base • Create an Enterprise Forum • Provide Assistance for the Preparation of SBIR/STTR • Open UPR Intellectual Property and Technology Commercialization Office (IPTC) to Entrepreneurs & Start-Ups Companies. • Create Infrastructure to Enable Innovation • Promote and support the formation of a system of incubators • Create R&D institutes to promote innovation • Advocacy and Promoting Systemic Thinking in the Development of S&T Innovation in Puerto Rico: Implementing the S&T Policy 44

  45. Building a High Performance Computing andINTERNET2 Informatics Infrastructurefor Research and Education 45

  46. High Performance Computing Facility • The High Performance Computing Facility was created in 1998, with NSF funding, to serve the computational needs of the research community; it provides: • Center for Numerical Supercomputing. • Bioinformatics Resource Center. • Two visualization laboratories. • Access Grid Video Conferencing Center. • Serves Puerto Rico’s Internet2 Services Alliance (PRISA net) GigaPoP. • Computing Facilities • Silicon Graphics Origin 300 32 MIPS 14000 Processors. • Silicon Graphics Origin 2400/Onyx 2 24 MIPS Processors. • Silicon Graphics Origin 2000 desk side cluster 16 MIPS desk side cluster. • Linux Supercluster 156 processors. 46

  47. Puerto Rico Internet 2 Services Association PRISA net Other Internet 2 Institutions National National Research Labs Supercomputing facilities RCM International Research OC-3 Facilities OC-3 = 155Mb/sec RRP Abilene OC-3 = 100xT1 OC-3 Centennial ATM Cloud OC-3 (Fiber optics) AO OC-3 OC-3 FIU GigaPOP ATM = OC-3 Asynchronous OC-3 (Quest on America II) Transfer Mode RUM OC-3 OC-3 Centennial OC-3 ATM PRISA GigaPOP PRISA will entertain alliances and partnerships on research and educational projects with industry and C of C members in Puerto Rico 47

  48. www.hpcf.upr.edu/prstp 48

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