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Dr D. Salomon, Clinique du Seujet Dermatologie, Genève denis.salomon@cidge.ch

PHOTOTHERAPIE DYNAMIQUE. Dr D. Salomon, Clinique du Seujet Dermatologie, Genève denis.salomon@cidge.ch. PHOTODETECTION PDD. Exposition. Lésion. PS. PS. Fluorescence. PS. Administration Pénétration. PS. PS. PS. PS. PS. PS. PS. PS. PS. Irradiance. Principe de la PDT.

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Dr D. Salomon, Clinique du Seujet Dermatologie, Genève denis.salomon@cidge.ch

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  1. PHOTOTHERAPIE DYNAMIQUE Dr D. Salomon, Clinique du Seujet Dermatologie, Genève denis.salomon@cidge.ch

  2. PHOTODETECTION PDD Exposition Lésion PS PS Fluorescence PS Administration Pénétration PS PS PS PS PS PS PS PS PS Irradiance Principe de la PDT Métabolisme Ciblage PHOTOTTT PDT Destruction de la Lésion DOULEUR

  3. Pénétration

  4. Pénétration

  5. Fig. 2. Typical fluorescence patterns after application of 20% 5-ALA cream under occlusion for: (A) 0.5 hour, (B) 1 hour, (C) 2 hours, and (D) 3 hours. Lasers in Surgery and Medicine 39:302–310 (2007)

  6. Métabolisme ?

  7. Ciblage Application Détection Action ciblée

  8. Fluoresc. reference Digital camera Violet LED + short pass filter Fluoresc. Long pass filter Light diffusion system Photodétection

  9. Weight: 630g Exposure area:  Ø40mm Emission Light intensity:   2mW Emitting wavelength:  400-420nm Measuring excitationwavelength:    610-720nm Sales: Dia-Medico.com 

  10. Détection semi-quantitative de la PpIX

  11. Avant TTT Délimitation + curetage

  12. Photodetection

  13. ALA M-ALA X-ALA

  14. Porphyrine spectre d‘absorption nm Stratum corneum Epidermis Dermis Subcutis Spectre d’absorption de la PpIXPénétration

  15. Irradiance

  16. Irradiance Diode laser 630 nm 0-150 mW/cm2 LED 635 +/- 3 nm 60 mW/cm2

  17. Figure 9 Different light delivery patterns with similar fluence.

  18. CONCLUSION Evaluer la fluorescence pour Apprécier le ciblage Anticiper les effets secondaires Contrôler l’efficacité du traitement ?

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