Heavy Metal Detoxification in the treatment of autism and the use of metyhlcobalamin

1. Heavy Metal Detoxification in the treatment of autism and the use of metyhlcobalamin Dr T.E. Gabriel Stewart M.B. B.CH B.A.O. M.I.C.G.P A.P.C.T

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3. 3 Topics (Contd.) Dealing with the yeast overgrowth. Dealing with the leaky gut. Heavy metals and their effects. Chelation. Methylcobalamin. Sources of information. Numerous heavy metals which are toxic the most toxic are lead,mercury,cadmium,arsenic,aluminium,antimony,tin,nickel,thallium as well as ones that are essential but dangerous in excess namely Iron and copper which we will discuss later Numerous heavy metals which are toxic the most toxic are lead,mercury,cadmium,arsenic,aluminium,antimony,tin,nickel,thallium as well as ones that are essential but dangerous in excess namely Iron and copper which we will discuss later

4. 4 GUT Issues must be dealt with before dealing with the heavy metal issue There are 3 main issues common to all autistic Children Yeast Overgrowth Leaky gut Heavy Metal Accumulation When they enter the bodythey go thro a chemical biological processcalled oxidation and form free radicals.It is now indisputed that free radical damagecontributes significantly to the degeneratuve process of ageing.Act akin to sparks in a fire damagingcells and resulting in the diseases so often reffered as the ageing diseases.when cells are damaged they no longer function properly resulting in damage to the tissues andfinally to the organs of the body.Symptoms may not appearfor yearsas the body stores these toxins in various tissues.Bones and fatty deposits.Symptoms of chronic metal toxicity are therefore insidiousand non specifucand include fatigue,malaise and increased susceptility to infections.Excessive free radical activity cannot be avoided in todays environment.When this dagenerative process happens to the cells in your body you can easily see why you do not have the energy you should.You don�t repair as well as u used to,u get older more quickly and u wear out much faster than you want.When this process affects your blood vessels u develop circulatory problems leading to poor skin texture etc etcWhen they enter the bodythey go thro a chemical biological processcalled oxidation and form free radicals.It is now indisputed that free radical damagecontributes significantly to the degeneratuve process of ageing.Act akin to sparks in a fire damagingcells and resulting in the diseases so often reffered as the ageing diseases.when cells are damaged they no longer function properly resulting in damage to the tissues andfinally to the organs of the body.Symptoms may not appearfor yearsas the body stores these toxins in various tissues.Bones and fatty deposits.Symptoms of chronic metal toxicity are therefore insidiousand non specifucand include fatigue,malaise and increased susceptility to infections.Excessive free radical activity cannot be avoided in todays environment.When this dagenerative process happens to the cells in your body you can easily see why you do not have the energy you should.You don�t repair as well as u used to,u get older more quickly and u wear out much faster than you want.When this process affects your blood vessels u develop circulatory problems leading to poor skin texture etc etc

5. 5 Yeast Overgrowth Yeast overgrowth leads to poor absorption of necessary vitamins, minerals & esssential nutrients. It is normal to have a small amount of yeast in the GI tract. Autistic children however have abnormal amounts, usually leading to poor absorption of essential nutrients and the leakage of toxic substances into the bloodstream which should not be absorbed.

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7. 7 Antioxidants in diet and producedin the body during the course of normal metabolism protect us by preventing these heavy metals from becoming oxidated and behaving as free radicals. Exaplles of antioxidants are etc etc.So a diet rich in these is advised.Antioxidants in diet and producedin the body during the course of normal metabolism protect us by preventing these heavy metals from becoming oxidated and behaving as free radicals. Exaplles of antioxidants are etc etc.So a diet rich in these is advised.

8. 8 Chelation WHAT IS IT? CHELATION �Greek Word �CHELE� which means � to claw� or to �GRASP�. Chelation Agents grasp the heavy metals and remove them via the kidneys EDTA is an IV treatment that chelates heavy metals but has little effect on Mercury. Therefore it is not the chelator of choice in Autism.

9. 9 Heavy Metals What are they ? Where do they come from ? What effect have they on our bodies ? How are we protected against these heavy metals/free radicals ? How are they removed ? How do they impact on our health when they are removed ? Toxic metals are everwhere putting a constant strain on our cells,the smallest working parts in our bodies. They abound in pesticides,hydrogenated fats,environmental pollutionsand a wide variety of industrial chemicals. They are in the air we breathe h2o and the food we eat Toxic metals are everwhere putting a constant strain on our cells,the smallest working parts in our bodies. They abound in pesticides,hydrogenated fats,environmental pollutionsand a wide variety of industrial chemicals. They are in the air we breathe h2o and the food we eat

10. 10 Heavy Metals � what are they and where do they come from Lead � petrol, paint, batteries, certain water mains Mercury � fillings in teeth, fish, paint, numerous appliances such as mercury thermometers, nasal sprays and eye drops, certain vaccines. Cadmium � Cigarettes, tyres, metal platings Arsenic � Pesticides, chicken feeds, rice, treated wood For ExampleFor Example

11. 11 Heavy Metals � what are they and where do they come from Aluminum � Cooking wares, aluminum foil, antacids, certain vaccines, canned drinks/foods Antimony � Carpets, flame retardant clothes Iron Copper

12. 12 Heavy Metals � how are we protected against these free radicals Diet /nutrition� �let food be your medicine and let medicine be your food�- Hippocrates Supplementation Skin release Good kidney eliminations Good bowel eliminations Exercise Healthy lifestyle Diet supplementation skinn release etc are all useful methods for dealing with heavy metals.Over time these natural processesare unable to defend us resulting in the diseases already mentionedDiet supplementation skinn release etc are all useful methods for dealing with heavy metals.Over time these natural processesare unable to defend us resulting in the diseases already mentioned

13. 13 What are the effects of these toxic metals overload They are oxidised to form free radicals resulting in the destruction of cells, They affect organs ,interfere with enzyme systems, inhibit prostaglandin formation. Weaken the immune system, inhibit the proper functioning of cells, contribute to gastrointestinal problems, and are carcinogenic.

14. 14 What Chelation agents are there EDTA-Ethylene diamine tetra acetic acid DMSA(dimercocaptosuccinic acid) DMPS(dimercaptopropanesulfonic acid) TTFD Transdermal Allithiamine

15. 15 How are they used EDTA is effective only intravenously.It is used in adults in the form of MG EDTA for Heart Disease,Circulatory disorders,neurological disorders, and the chronic degenerative diseases. DMSA (dimercocaptosuccinic acid) DMPS(Dimercaptopropanesulfonic acid) TTFD/allathiamine (active form of B1)

16. 16 EDTA and its safety Given according to ACAM protocol millions of chelations in past 30 years no recorded death. Doctors licensed in western Canada since 1997 No serious ADRS NIH conducting $30 million clinical trial on 2,300 patients no serious adrs NIH 800,000 I.V EDTA chelations in U.S. alone no serious ADRS Not suitable for ASD children 3 hour i.v. inneffective in chelating mercury Powerful chelator of all other toxic heavy metals

17. 17 Metal Dertoxification in Auistic children DMSA is the most widely used , convenient, safe , and given orally. It is a good chelator of Mercury, Lead and Cadmium. Dmps May be given intravenously. A good chelator of mercury,often used as a provovative agent, usually given in oral form

18. 18 Chelating With the oral chelators DMSA is given orally according to the Dan protocol 10mg/kg body weight/3times daily for three days on and 11 days off. Repeat Full Blood Count and Blood chemistry tests at 3 to 4 month intervals. Mobilization and excretion of the heavy metals produces a shift in the equilibrium between the various compartments of the body. This exerts an almost magnetic effect on metals in depots which are not directly accessible to the chelating agent. The body attempts to restore an equilibrium between the depots again. The heavy metals will then migrate partially into compartmenst where it is accessible to the chelating agent.

19. 19 Advantages of DMSA over DMPS DMSA more widley used therefore greater experience with its use and well established safety profile. Well established in the DAN protocol. No well established oral DMPS protocol. DMPS used more in acute poisoning with Lead, Mercury, Arsenic etc. DMSA is more effective in removing Mercury from the brain, particularly when combined with Alpha Lipoic Acid.

20. 20 Disadvantages of DMSA oral therpay DMSA may feed into the yeast/leaky gut/Gastrointestinal problems. DMPS is not as severe on the gastrointestinal problems DMPS used by some physiciansina once weekly dosage of 100 mg per week Is over 50 % absorbed

21. 21 Other Heavy Metal Detox Options Reduced Glutathione Alpha Lipoic Acid N-Acteyl Cysteine TTFD-Allithiamine Transdermal DMPS Transdermal DMSA

22. 22 Methylcobalamin and pharmacology Metylathion is the process by which a single Carbon atom is transferred from a Methyl donor to another molecule.This process is essential to life itself. Dr. Richard Deth of Boston believes that Thiomersail interferes with the Metylathion process in converting Vitamin B12 to Metylcobalamin. In many cases Autsim can be treated effectively by the Administration of Metyl B12 to augment the Metylathion capacity.

23. 23 Biosynthesis of Active Methylcobalamin The low levels of Glutathione in autistic children will adversely affect their ability to detoxify and protect against heavy metals such as Thiomersal.

24. 24 Impaired Methylation As impaired Methylation is important in Autism, the administration of Methylcobalamin should bring about an improvement. Dr. James Neubrander has found significant improvement with injections of Methylcobalamin by giving the Methylcobalamin every 3 days. Improvements were noted in Attention, language ability and social skills.

25. 25 How is Methylcobalamin given? Dosage recommendation is 65 micrograms per Kilogram Bodyweight every 3 days. This means that as much as 1250 micrograms is present in 0.05ml The needle 30 gauge 3/10 Ultrafine BD insulin. It may be given by the parent while the child is sleeping. It is inserted into the buttock at a 30 � 45 degree angle just under the skin.

26. 26 Adverse effects Stimming Hyperactivity Should these effects occur one does not necessarily stop the treatment. If Adverse effects are tolerable the treatment should continue

27. 27 Concentrated Metylcobalamin by Injection Metylcobalamin is the active Co-enzyme element of B12 B12 is present in the brain and central nervous system as Metylcobalamin & is Non toxic. It is known that Metylcobalamin metabolism is impaired in the Autistic child. Much information on this is available for Dr. Neubrander.

28. 28 Multi dimensional approach It should be remembered that improving Methylation capacity is only one component of the multi dimensional approach in the treatment of Autism. Gluten Casein free diet Nutritional supplementation Chelation Behavioural therapies

29. 29 Sources of Information www.chelation-ireland.com www.ACAM.org Children with Starving Brains Jaquelyn McCandless, MD ISBN 1-883647-10-X Biological treatments for Treatments for Autism and PDD by William Shaw Ph.D ISBN 0-9661238-1-6 Tests www.greatplainslaboratory.com Autism Research Institute www.autism.com

30. 30 Contact Details Dr T.E.Gabriel Stewart 29 Hawthorn Lodge, Castleknock, Dublin15, Ireland Telephone: +353-1-8212540 Fax : +353-1-8128370 drgabrielstewart@eircom.net