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Pathophysiology

Pathophysiology. Infant is responding to allergens in mom’s diet Cows milk protein and soy are most common Sensitization could start in utero Occasionally symptoms are seen day 1 Restricting mom’s diet during pregnancy currently not recommended

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Pathophysiology

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  1. Pathophysiology • Infant is responding to allergens in mom’s diet • Cows milk protein and soy are most common • Sensitization could start in utero • Occasionally symptoms are seen day 1 • Restricting mom’s diet during pregnancy currently not recommended • Large bowel edema, erosions of mucosa, eosinophilic infiltration of the intestinal lining

  2. BMC gastroenterology 2011 11:82

  3. Maternal Elimination DietABM protocol • Start with elimination of cows milk products • Most cases will improve in 72-96 hours • No more blood, mucous is gone, stools appear normal • If no change at all after 2 weeks, also eliminate soy. If no change, add dairy and soy back into the diet, and eliminate something else. Continue in this way with other allergens. • Citrus fruits, eggs, nuts, peanut, wheat, corn, strawberries, chocolate • Families need education on how to read food labels to avoid substances of each allergen. • Geographic variability in the most common allergens

  4. Severe Cases • Consider starting with a strict maternal elimination diet • Lamb, pears, squash, rice • Once symptoms resolve, add a new allergen once a week • Addition of pancreatic enzymes • No randomized controlled trials • Theoretically breaks down allergens in mom’s gut before absorption • Two Creon 6000 with each meal, one with each snack

  5. Breastfed Babies Receiving Formula Supplementation • Change to a soy based formula first. • If sx are severe and persistent, change to a hydrolyzed formula, or possibly an amino acid-based formula

  6. Re-introducing Allergens • Consider allergy testing if other allergic symptoms such as eczema, allergies, hives, chronic diarrhea • If baby otherwise well, OK to reintroduce offending allergens 6-9 mo after initial reaction, or wait until 12 moold

  7. Other Website Resources • Web Links • ILCA, Academy of Nutrition and Dietetics • Resources for recipes • Food allergy information

  8. Future Research • Further defining the relationship between these gastropathies • Incidence in the population • Who is more at risk? • Other means of identifying offending antigens • Further research on maternal treatment such as pancreatic enzymes

  9. Check Out www.infantproctocolitis.org

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