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Chapter 70

Chapter 70. Weight Management. Drug Overview. Anorexiants Mixed neurotransmitter reuptake inhibitor Sympathomimetic Lipase Inhibitors  Indications. Mechanism of Action. sibutramine phentermine orlistat. Treatment Principles. Standardized Guidelines

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Chapter 70

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  1. Chapter 70 Weight Management

  2. Drug Overview • Anorexiants • Mixed neurotransmitter reuptake inhibitor • Sympathomimetic • Lipase Inhibitors  • Indications

  3. Mechanism of Action • sibutramine • phentermine • orlistat

  4. Treatment Principles • Standardized Guidelines • U.S. Preventive Services Task Force: Guidelines for screening for obesity in adults, revised 2003. • National Heart, Lung, and Blood Institute at NIH: Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults, 2003

  5. Treatment Principles • Evidence-Based Recommendations • Cardinal Points of Treatment • Nonpharmacologic Treatment • Diet • Exercise • Behavior • Surgery

  6. Treatment Principles • Pharmacologic Treatment • NHLBI guidelines • Role of diet and exercise • sibutramine • phentermine • orlistat • Herbal and OTC preparations • Evaluation of patients who have taken dexfenfluramine or fenfluramine

  7. Treatment Principles • How to Monitor • Patient Variables • Geriatrics • Pediatrics • Pregnancy and lactation • Patient Education

  8. Anorexiants • sibutramine (Meridia) • Contraindications • Warnings • Precautions • Pharmacokinetics • Adverse effects • Drug interactions • Dosage and administration

  9. Anorexiants • phentermine (Fastin, Ionamin) • Contraindications • Warnings • Precautions • Adverse effects • Dosage and administration

  10. Lipase Inhibitors • orlistat (Xenical, Alli [OTC]) • Contraindications • Warnings • Precautions • Overdosage • Dosage and administration

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