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Involvement of CD44, “a molecule with thousand faces”, in autoimmune diseases

Involvement of CD44, “a molecule with thousand faces”, in autoimmune diseases Nathalie Assayag-Asherie, Itshak Golan, Lola Weiss, Lora Eshkar Sebban, Shimon Slavin, Itamar Raz and David Naor Supported by: D Cure Diabetes care in Israel and The Israel Academy of Sciences

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Involvement of CD44, “a molecule with thousand faces”, in autoimmune diseases

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  1. Involvement of CD44, “a molecule with thousand faces”, in autoimmune diseases Nathalie Assayag-Asherie, Itshak Golan, Lola Weiss, Lora Eshkar Sebban, Shimon Slavin, Itamar Raz and David Naor Supported by: D Cure Diabetes care in Israel and The Israel Academy of Sciences Israel Science Foundation

  2. The inflammatory process

  3. GENOMIC STRUCTURE OF THE CD44 MOLECULE

  4. In collaboration with Professor Yehiel Zick The Weizmann Institute

  5. CD44 FUNCTIONS *Cell-cell and cell-matrix interactions * Support of cell migration * Signal delivery for cell growth and cell differentiation * Transmission of apoptotic signals * Signal delivery for cell survival * Signal delivery for production of cytokines and chemokines * Presentation of chemokines and growth factors to cells with corresponding receptors * Docking of proteolytic enzymes on the cell surface and their presentation to relevant substrates * Internalization and degradation of hyaluronic acid

  6. The inflammatory process

  7. Anti-CD44 mAbs reduce pathological activities in the following experimental diseases:

  8. Dr Lola Weiss Department of Bone Marrow Transplantation and Cancer Research Laboratory, Hadassah University Hospital, Jerusalem, Israel

  9. Nathalie Assayag Asherie The Lautenberg Center for General and Tumor Immunology, Hebrew University-Hadassah Medical School, Jerusalem, Israel

  10. Anti-CD44 mAb reduces insulitis in NOD micehistopathological analysis PNAS,97:285,2000

  11. Dr Itshak Golan

  12. GENOMIC STRUCTURE OF THE CD44 MOLECULE

  13. Sequence of V4-V5 junction in CD44v3-v10 of Keratinocytes in normal donors 4 5 VARIANT EXON VARIANT EXON AT GTA GAC ATG ACT G V D M T D J. Clin . Invest. 111:1211 - 1220 (2003)

  14. Binding of F8:33 Anti - CD44vRA mAb to Synovial Fluid Cells of an RA Patient but not to his own PBLs

  15. Question Is the binding of anti-CD44 mAb to cell surface CD44 delivers intracellular signaling leading to a functional outcome, such as apoptosis ?

  16. Anti-CD44vRA mAb + Anti-CD44vRA mAb +

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