1 / 15

Neuregulin and Schizophrenia

Neuregulin and Schizophrenia. Schizophrenia. Debilitating mental illness affecting 1 % of the general population across the world. Onset in adolescent age. Symptoms Positive symptoms Hallucinations, delusions Negative symptoms Avolition, Apathy Disorganization symptoms

malik-odonnell
Télécharger la présentation

Neuregulin and Schizophrenia

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Neuregulin andSchizophrenia

  2. Schizophrenia • Debilitating mental illness affecting 1 % of the general population across the world. • Onset in adolescent age. Symptoms • Positive symptoms • Hallucinations, delusions • Negative symptoms • Avolition, Apathy • Disorganization symptoms • Inappropriate social behavior • Cognitive deficits • Perceptual deficits - Visual, Auditory. • Deficits in memory. • Emotional changes.

  3. Schizophrenia is associated with many alterations in brain structure and function. Many regional reduction in gray matter. Reduction in brain activation during cognitive tasks Van der stelt et al., , 2005 Thompson et al., , 2001 Achim et al., , 2005

  4. Genetics of Schizophrenia Kirov et al., , 2003

  5. Neuregulin 1 – Linkage in 8p Stefansson et al., 2002

  6. Harrison et al., 2006

  7. Functions of Neuregulin

  8. Flames et al., 2004

  9. Chih et al., 2004

  10. Michailo et al., 2004

  11. Conclusions • Evidences so far, show NRG plays a vital role in neurodevelopmental processes. • Association with Schizophrenia and late onset Alzhimer’s suggest a link between this gene and various diseases of nervous system. • The role of NRG is still being studied. Further studies are required to identify its mechanisms of action.

  12. Catpa demo….

More Related